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• W2015432704 abstract "Background/Purpose: Melanogenesis can be induced in vitro in melanoma cells and melanocytes by adding substances able to neutralize intracellular acidic organelles like melanosomes. Further addition of l ‐tyrosine enhances the melanogenesis by increasing the tyrosinase activity. As such, the property of tyrosine as a pigmentation enhancer is used in promoting creams containing tyrosine. The objective of this study was to investigate whether such an effect could actually be seen in a short term in vivo mouse study. Methods: Lightly pigmented C3.Cg/TifBomTac hairless mice capable of pigmenting had ammonium chloride (NH 4 Cl) and/or l ‐tyrosine applied topically (1/day for 3 weeks). Pigmentation of the mice was determined using the Kodak Gray Scale at days 0, 7, 14, and 21. Results: Both NH 4 Cl and l ‐tyrosine yielded no significant effect, either alone or in combination, when applied using either hydrogel or moisturizing cream. Exposing mice to simulated solar radiation (4 standard erythema doses, 3/week) yielded increased pigmentation. However, no statistically significant difference was found between treatment with simulated solar radiation alone or in combination with NH 4 Cl and l ‐tyrosine. Conclusion: In spite of the commercial value of adding l ‐tyrosine to ‘pigmentation‐enhancing’ creams, topically applied l ‐tyrosine showed no pigmentation‐enhancing effect, neither alone nor in combination with ultraviolet (UV) radiation, providing a basis to contest such promotional measures." @default.
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• W2015432704 date "2007-08-30" @default.
• W2015432704 modified "2023-10-16" @default.
• W2015432704 title "Ammonium chloride and l-tyrosine enhance melanogenesis in vitro but not in vivo even in combination with ultraviolet radiation" @default.
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• W2015432704 doi "https://doi.org/10.1111/j.1600-0781.2007.00307.x" @default.
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