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- W2015432866 endingPage "326" @default.
- W2015432866 startingPage "312" @default.
- W2015432866 abstract "Gene amplification in human cancer cells generates two cytogenetically identifiable structures: extrachromosomal double minutes (DMs) and the chromosomal homogeneously staining region (HSR). DMs are composed of autonomously replicating circular DNA of genomic origin, and they tell us about how the extrachromosomal elements may behave in the cells, how they were entrapped by the micronuclei and how they were eliminated from the cells. On the other hand, the episome model predicts that extrachromosomal elements excised from the chromosome arm might generate DMs, and the breakage-fusion-bridge (BFB) cycle model explains the generation of the HSR. In accordance with this, a plasmid bearing a mammalian replication initiation region (IR) and a matrix attachment region (MAR) mimics gene amplification and generates DMs and HSRs de novo. The IR/MAR gene amplification system extends our understanding on the mechanism of gene amplification and the behavior of amplified genes. Furthermore, the system may suggest the way how extrachromosomal elements in general may alter the chromosome architecture and function." @default.
- W2015432866 created "2016-06-24" @default.
- W2015432866 creator A5020512644 @default.
- W2015432866 date "2009-01-01" @default.
- W2015432866 modified "2023-10-10" @default.
- W2015432866 title "Extrachromosomal Double Minutes and Chromosomal Homogeneously Staining Regions as Probes for Chromosome Research" @default.
- W2015432866 cites W120074575 @default.
- W2015432866 cites W130386237 @default.
- W2015432866 cites W1487534034 @default.
- W2015432866 cites W1490562023 @default.
- W2015432866 cites W1496334793 @default.
- W2015432866 cites W1530643919 @default.
- W2015432866 cites W1588968785 @default.
- W2015432866 cites W1919521419 @default.
- W2015432866 cites W1920718601 @default.
- W2015432866 cites W1953332264 @default.
- W2015432866 cites W1959134117 @default.
- W2015432866 cites W1967250409 @default.
- W2015432866 cites W1970245450 @default.
- W2015432866 cites W1972199640 @default.
- W2015432866 cites W1978556663 @default.
- W2015432866 cites W1981776102 @default.
- W2015432866 cites W1983345968 @default.
- W2015432866 cites W1985704463 @default.
- W2015432866 cites W1986142424 @default.
- W2015432866 cites W1987970841 @default.
- W2015432866 cites W1988073250 @default.
- W2015432866 cites W1994419156 @default.
- W2015432866 cites W1994718088 @default.
- W2015432866 cites W1995425986 @default.
- W2015432866 cites W1995561460 @default.
- W2015432866 cites W1995782808 @default.
- W2015432866 cites W1995873584 @default.
- W2015432866 cites W199827678 @default.
- W2015432866 cites W1999804314 @default.
- W2015432866 cites W2001645238 @default.
- W2015432866 cites W2003527666 @default.
- W2015432866 cites W2004116111 @default.
- W2015432866 cites W2004215286 @default.
- W2015432866 cites W2004691672 @default.
- W2015432866 cites W2006838513 @default.
- W2015432866 cites W2011270372 @default.
- W2015432866 cites W2013755918 @default.
- W2015432866 cites W2013892708 @default.
- W2015432866 cites W2014037288 @default.
- W2015432866 cites W2014401442 @default.
- W2015432866 cites W2021569333 @default.
- W2015432866 cites W2023447778 @default.
- W2015432866 cites W2028897163 @default.
- W2015432866 cites W2029009493 @default.
- W2015432866 cites W2031220269 @default.
- W2015432866 cites W2033250845 @default.
- W2015432866 cites W2034649293 @default.
- W2015432866 cites W2034666565 @default.
- W2015432866 cites W2044142379 @default.
- W2015432866 cites W2046221162 @default.
- W2015432866 cites W2047310903 @default.
- W2015432866 cites W2053728456 @default.
- W2015432866 cites W2056362680 @default.
- W2015432866 cites W2057037996 @default.
- W2015432866 cites W2058123255 @default.
- W2015432866 cites W2061829784 @default.
- W2015432866 cites W2062083469 @default.
- W2015432866 cites W2066410692 @default.
- W2015432866 cites W2067743673 @default.
- W2015432866 cites W2069789037 @default.
- W2015432866 cites W2071171955 @default.
- W2015432866 cites W2071793771 @default.
- W2015432866 cites W2071867288 @default.
- W2015432866 cites W2071905683 @default.
- W2015432866 cites W2075233656 @default.
- W2015432866 cites W2075547944 @default.
- W2015432866 cites W2079086920 @default.
- W2015432866 cites W2079384901 @default.
- W2015432866 cites W2080976322 @default.
- W2015432866 cites W2084244820 @default.
- W2015432866 cites W2087909839 @default.
- W2015432866 cites W2089033365 @default.
- W2015432866 cites W2092956510 @default.
- W2015432866 cites W2094133559 @default.
- W2015432866 cites W2095156669 @default.
- W2015432866 cites W2096256558 @default.
- W2015432866 cites W2097061555 @default.
- W2015432866 cites W2102618729 @default.
- W2015432866 cites W2105190923 @default.
- W2015432866 cites W2108172661 @default.
- W2015432866 cites W2109288488 @default.
- W2015432866 cites W2109876504 @default.
- W2015432866 cites W2110508317 @default.
- W2015432866 cites W2112784018 @default.
- W2015432866 cites W2115281458 @default.
- W2015432866 cites W2116969265 @default.
- W2015432866 cites W2117741144 @default.
- W2015432866 cites W2118853072 @default.
- W2015432866 cites W2119480933 @default.
- W2015432866 cites W2120321636 @default.
- W2015432866 cites W2121892027 @default.
- W2015432866 cites W2126414913 @default.