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- W2015433401 endingPage "e0120281" @default.
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- W2015433401 abstract "This study investigates the electrophysiological properties and functional integration of different phenotypes of transplanted human neural precursor cells (hNPCs) in immunodeficient NSG mice. Postnatal day 2 mice received unilateral injections of 100,000 GFP+ hNPCs into the right parietal cortex. Eight weeks after transplantation, 1.21% of transplanted hNPCs survived. In these hNPCs, parvalbumin (PV)-, calretinin (CR)-, somatostatin (SS)-positive inhibitory interneurons and excitatory pyramidal neurons were confirmed electrophysiologically and histologically. All GFP+ hNPCs were immunoreactive with anti-human specific nuclear protein. The proportions of PV-, CR-, and SS-positive cells among GFP+ cells were 35.5%, 15.7%, and 17.1%, respectively; around 15% of GFP+ cells were identified as pyramidal neurons. Those electrophysiologically and histological identified GFP+ hNPCs were shown to fire action potentials with the appropriate firing patterns for different classes of neurons and to display spontaneous excitatory and inhibitory postsynaptic currents (sEPSCs and sIPSCs). The amplitude, frequency and kinetic properties of sEPSCs and sIPSCs in different types of hNPCs were comparable to host cells of the same type. In conclusion, GFP+ hNPCs produce neurons that are competent to integrate functionally into host neocortical neuronal networks. This provides promising data on the potential for hNPCs to serve as therapeutic agents in neurological diseases with abnormal neuronal circuitry such as epilepsy." @default.
- W2015433401 created "2016-06-24" @default.
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- W2015433401 date "2015-03-12" @default.
- W2015433401 modified "2023-10-13" @default.
- W2015433401 title "Functional Integration of Human Neural Precursor Cells in Mouse Cortex" @default.
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- W2015433401 cites W1936342032 @default.
- W2015433401 cites W1967100899 @default.
- W2015433401 cites W1974478434 @default.
- W2015433401 cites W1979840866 @default.
- W2015433401 cites W1981621010 @default.
- W2015433401 cites W1983482520 @default.
- W2015433401 cites W1986561732 @default.
- W2015433401 cites W1989921112 @default.
- W2015433401 cites W1999696388 @default.
- W2015433401 cites W2003735806 @default.
- W2015433401 cites W2003835684 @default.
- W2015433401 cites W2005594880 @default.
- W2015433401 cites W2006925855 @default.
- W2015433401 cites W2012705486 @default.
- W2015433401 cites W2014277329 @default.
- W2015433401 cites W2015500392 @default.
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- W2015433401 cites W2097454127 @default.
- W2015433401 cites W2101216536 @default.
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- W2015433401 cites W2159117162 @default.
- W2015433401 cites W2164928089 @default.
- W2015433401 cites W2166364179 @default.
- W2015433401 cites W2170661153 @default.
- W2015433401 cites W2171551522 @default.
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- W2015433401 doi "https://doi.org/10.1371/journal.pone.0120281" @default.
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