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- W2015436306 abstract "In this study in sheep with differing nutritional status, the authors present a model to investigate local as well as systemic effects of recombinant IGF-1 on hind limb muscle metabolism. Recombinant human IGF-1 (12.3;jbg-kg-h) was infused for 4 hours directly into the left femoral artery. The rates of protein synthesis, degradation, and gain of protein in the treated (infused) and contralateral limbs of well-fed, feeding-restricted, and starved sheep were calculated by the kinetics of L-12,6-_Hlphenylalanine infused into the jugular vein (8.5 kBq-min for 8 hours). Reducing feed intake decreased net protein gain of hind limb muscles, reduced hind limb glucose uptake, and lowered arterial concentration of IGF-1, insulin, glucose, phenylalanine, tyrosine, and isoleucine. The effect of nutrition on IGF binding proteins (IGFBP) was generally small; IGFBP-2 was more abundant in fasted animals. Infusion of IGF-1 into the left femoral artery increased plasma IGF-1 levels 2- to 4-fold in the left femoral vein, an..." @default.
- W2015436306 created "2016-06-24" @default.
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- W2015436306 date "1997-03-01" @default.
- W2015436306 modified "2023-09-27" @default.
- W2015436306 title "Insulin-Like Growth Factor 1 Inhibits Degradation and Improves Retention of Protein in Hindlimb Muscle of Lambs" @default.
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- W2015436306 doi "https://doi.org/10.1177/0148607197021002115" @default.
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