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• W2015438051 endingPage "e1000352" @default.
• W2015438051 startingPage "e1000352" @default.
• W2015438051 abstract "The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade of HSV gene transcription is initiated by the multifunctional virion protein VP16, which is expressed late in the viral replication cycle. Currently, it is widely accepted that VP16 transactivating function is not involved in the exit from latency. Utilizing the mouse ocular model of HSV pathogenesis together with genetically engineered viral mutants and assays to quantify latency and the exit from latency at the single neuron level, we show that in vivo (i) the VP16 promoter confers distinct regulation critical for viral replication in the trigeminal ganglion (TG) during the acute phase of infection and (ii) the transactivation function of VP16 (VP16TF) is uniquely required for the exit from latency. TG neurons latently infected with the VP16TF mutant in1814 do not express detectable viral proteins following stress, whereas viruses with mutations in the other major viral transcription regulators ICP0 and ICP4 do exit the latent state. Analysis of a VP16 promoter/reporter mutant in the background of in1814 demonstrates that the VP16 promoter is activated in latently infected neurons following stress in the absence of other viral proteins. These findings support the novel hypothesis that de novo expression of VP16 regulates entry into the lytic program in neurons at all phases of the viral life cycle. HSV reactivation from latency conforms to a model in which stochastic derepression of the VP16 promoter and expression of VP16 initiates entry into the lytic cycle." @default.
• W2015438051 created "2016-06-24" @default.
• W2015438051 creator A5040394865 @default.
• W2015438051 creator A5048851283 @default.
• W2015438051 creator A5079037023 @default.
• W2015438051 date "2009-03-27" @default.
• W2015438051 modified "2023-10-18" @default.
• W2015438051 title "De Novo Synthesis of VP16 Coordinates the Exit from HSV Latency In Vivo" @default.
• W2015438051 cites W1567025402 @default.
• W2015438051 cites W1580270992 @default.
• W2015438051 cites W1603733798 @default.
• W2015438051 cites W1681300846 @default.
• W2015438051 cites W1786943680 @default.
• W2015438051 cites W1789379901 @default.
• W2015438051 cites W1816590717 @default.
• W2015438051 cites W1889513504 @default.
• W2015438051 cites W1898630910 @default.
• W2015438051 cites W1903481747 @default.
• W2015438051 cites W192711870 @default.
• W2015438051 cites W1938545417 @default.
• W2015438051 cites W1942310387 @default.
• W2015438051 cites W1957140132 @default.
• W2015438051 cites W1967616351 @default.
• W2015438051 cites W1968735864 @default.
• W2015438051 cites W1969468255 @default.
• W2015438051 cites W1971292289 @default.
• W2015438051 cites W1979772713 @default.
• W2015438051 cites W1982232341 @default.
• W2015438051 cites W1988736583 @default.
• W2015438051 cites W1990196659 @default.
• W2015438051 cites W1991892508 @default.
• W2015438051 cites W1995796039 @default.
• W2015438051 cites W1997218722 @default.
• W2015438051 cites W2001476460 @default.
• W2015438051 cites W2002896353 @default.
• W2015438051 cites W2007986168 @default.
• W2015438051 cites W2008461865 @default.
• W2015438051 cites W2013607556 @default.
• W2015438051 cites W2018822795 @default.
• W2015438051 cites W2025495144 @default.
• W2015438051 cites W2027341342 @default.
• W2015438051 cites W2033811554 @default.
• W2015438051 cites W2036173058 @default.
• W2015438051 cites W2036301707 @default.
• W2015438051 cites W2040114529 @default.
• W2015438051 cites W2042122512 @default.
• W2015438051 cites W2043117997 @default.
• W2015438051 cites W2043238718 @default.
• W2015438051 cites W2047683017 @default.
• W2015438051 cites W2056295530 @default.
• W2015438051 cites W2056650797 @default.
• W2015438051 cites W2057232864 @default.
• W2015438051 cites W2058071990 @default.
• W2015438051 cites W2059823369 @default.
• W2015438051 cites W2060400133 @default.
• W2015438051 cites W2064433163 @default.
• W2015438051 cites W2066278365 @default.
• W2015438051 cites W2072229797 @default.
• W2015438051 cites W2073358204 @default.
• W2015438051 cites W2080862497 @default.
• W2015438051 cites W2094701018 @default.
• W2015438051 cites W2095491514 @default.
• W2015438051 cites W2097836651 @default.
• W2015438051 cites W2100404477 @default.
• W2015438051 cites W2102473073 @default.
• W2015438051 cites W2103552572 @default.
• W2015438051 cites W2105383433 @default.
• W2015438051 cites W2106013715 @default.
• W2015438051 cites W2106534896 @default.
• W2015438051 cites W2107380406 @default.
• W2015438051 cites W2111812925 @default.
• W2015438051 cites W2112244651 @default.
• W2015438051 cites W2113285831 @default.
• W2015438051 cites W2118408527 @default.
• W2015438051 cites W2118882782 @default.
• W2015438051 cites W2122280181 @default.
• W2015438051 cites W2122292756 @default.
• W2015438051 cites W2125018159 @default.
• W2015438051 cites W2127157516 @default.
• W2015438051 cites W2127846162 @default.
• W2015438051 cites W2129129906 @default.
• W2015438051 cites W2132050737 @default.
• W2015438051 cites W2132869978 @default.
• W2015438051 cites W2134279163 @default.
• W2015438051 cites W2134635475 @default.
• W2015438051 cites W2135412522 @default.
• W2015438051 cites W2138047853 @default.
• W2015438051 cites W2138565985 @default.
• W2015438051 cites W2139798327 @default.
• W2015438051 cites W2140178603 @default.
• W2015438051 cites W2140938030 @default.
• W2015438051 cites W2141424564 @default.
• W2015438051 cites W2141955811 @default.
• W2015438051 cites W2142423423 @default.
• W2015438051 cites W2149976919 @default.
• W2015438051 cites W2150698307 @default.
• W2015438051 cites W2151233410 @default.
• W2015438051 cites W2151802519 @default.

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