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- W2015438414 abstract "Abstract The effects of methylglyoxal-bis(guanylhydrazone) on selected cellular immune functions and on S-adenosylmethionine decarboxylase activity were studied in spleen cells from mice given sublethal doses of this drug. The development of antibody-forming cells was markedly inhibited after administration of methylglyoxal-bis(guanylhydrazone) whereas the functions of cytotoxic effector cells and phagocytes were not affected. The activity of S-adenosylmethionine decarboxylase was found to be greatly increased in spleen cells from mice given the drug, and this increase was 4- to 5-fold greater in nylon wool-adherent cell populations as compared to that in non-adherent cell populations. The uptake of methylglyoxal-bis(guanylhydrazone) was 1.5- to 2-fold greater in nylon wool-adherent cells than in non-adherent cells. These studies suggest that methylglyoxal-bis(guanylhydrazone) selectively affects antibody-forming cells among mouse spleen cell populations." @default.
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- W2015438414 date "1977-04-01" @default.
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- W2015438414 title "Selective effects of methylglyoxal-bis-(guanylhydrazone) on the development of antibody-forming cells in mice" @default.
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- W2015438414 doi "https://doi.org/10.1016/0006-2952(77)90215-5" @default.
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