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• W2015439745 abstract "<i>Background and Objectives:</i> Since gastric acidity and ascorbate play a critical role in the solubilization and reduction of iron for subsequent absorption, the achlorhydria associated with autoimmune and <i>Helicobacter pylori</i> gastritis may explain the poor response of such patients to oral iron treatment. In order to circumvent this problem, we explored the therapeutic potential of a duodenal formulation of ferrous glycine sulfate consisting of micropellets that do not dissolve at the acid environment of the stomach but, owing to their solubility at a higher pH, discharge their content directly into the duodenum. <i>Design and Methods:</i> In a case-control study, the treatment results of 39 patients with iron deficiency anemia receiving a duodenal formulation of ferrous glycine sulfate (group A) were compared with the results of 39 patients receiving other oral iron compounds (group B). Autoimmune gastritis, <i>H. pylori </i>gastritis or both were present in over 75% of patients in each group. <i>Results:</i> After 1 and 3 months of treatment, mean hemoglobin in group A increased from 9.5 ± 1.2 to 11.2 ± 1.3 and 12.8 ± 1.3 g/dl, respectively. By comparison, in group B, the corresponding values increased from 9.3 ± 1.3 to 10.2 ± 1.5 (p = 0.019) and 11.1 ± 1.7 g/dl (p = 0.022). A favorable response, defined as a more than 2 g/dl increase in basal hemoglobin or hemoglobin exceeding 12 g/dl, was obtained in 33 of 39 patients in group A compared with only 18 of 39 in group B (p = 0.009). Because of treatment failure, 14 patients in group B were subsequently referred for intravenous ferric sucrose therapy versus only 3 in group A (p < 0.0001). Conversely, of 5 patients in group A managed by intravenous iron prior to referral, 4 became independent of parenteral iron after starting the duodenal formulation of ferrous glycine sulfate. <i>Interpretation and Conclusions:</i> In patients with iron deficiency anemia associated with autoimmune and <i>H. pylori</i> gastritis with a high rate of refractoriness to oral iron treatment, satisfactory response to a duodenal formulation of ferrous glycine sulfate can be elicited in the vast majority of cases, obviating the need for expensive, inconvenient and occasionally risky intravenous iron administration." @default.
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• W2015439745 date "2007-01-01" @default.
• W2015439745 modified "2023-09-25" @default.
• W2015439745 title "Decreased Treatment Failure Rates following Duodenal Release Ferrous Glycine Sulfate in Iron Deficiency Anemia Associated with Autoimmune Gastritis and <i>Helicobacter pylori</i> Gastritis" @default.
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• W2015439745 doi "https://doi.org/10.1159/000101701" @default.
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