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- W2015440552 abstract "Nestin-positive cells were seen around the damaged area at 24 h, 72 h and 7 days after rat traumatic brain injury. Tissue was isolated from around the damaged area at 72 h after injury and spheres were cultured with basic fibroblast growth factor and epidermal growth factor. These spheres could not be isolated at 24 h and 7 days after injury. Isolated spheres consisted of nestin-positive neural stem cells. Neurospheres differentiated into Tuj1-positive, glial fibrillary acidic protein-positive and O4-positive cells after 4 days in culture without basic fibroblast growth factor and epidermal growth factor. These results indicate that isolated and cultured neurospheres can differentiate into neurons and glia. An increase in nestin-positive cells around a cerebral cortical damaged area might contribute to neurogenesis and neuroplasticity." @default.
- W2015440552 created "2016-06-24" @default.
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- W2015440552 date "2005-10-17" @default.
- W2015440552 modified "2023-10-05" @default.
- W2015440552 title "Isolation of neural stem cells from damaged rat cerebral cortex after traumatic brain injury" @default.
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- W2015440552 doi "https://doi.org/10.1097/01.wnr.0000183330.44112.ab" @default.
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