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- W2015440689 abstract "Oncology chemotherapeutics frequently exhibit a narrow therapeutic index, further complicated by the serious nature of dosing either too high (dangerous toxicities) or too low (loss of antitumor benefits). This underscores the need for optimal individualized drug selection and dosing, especially with agents that have wide interpatient variability. Pharmacogenomic assessment of drug metabolizing enzymes can improve the ability to optimally dose patients being treated with certain agents such as 6-mercaptopurine, irinotecan, tamoxifen, and flurouracil. Two of these agents (6-mercaptopurine and irinotecan) already have mention of pharmacogenomic testing in their FDA approved package inserts. Ongoing retrospective and prospective trials will help to further optimize the place in clinical practice for not only performing these pharmacogenomic assessments but, more importantly, how the results should be incorporated into therapy dosing decisions for patients." @default.
- W2015440689 created "2016-06-24" @default.
- W2015440689 creator A5024023641 @default.
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- W2015440689 date "2012-08-01" @default.
- W2015440689 modified "2023-10-05" @default.
- W2015440689 title "Pharmacogenomic Applications in Oncology" @default.
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- W2015440689 doi "https://doi.org/10.1177/0897190012448308" @default.
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