Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015441623> ?p ?o ?g. }
- W2015441623 endingPage "660" @default.
- W2015441623 startingPage "651" @default.
- W2015441623 abstract "Schizosaccharomyces pombe cells divide by medial fission. One class of cell division mutants (cdc), the late septation mutants, defines four genes: cdc3, cdc4, cdc8, and cdc12 (Nurse, P., P. Thuriaux, and K. Nasmyth. 1976. Mol. & Gen. Genet. 146:167-178). We have cloned and characterized the cdc4 gene and show that the predicted gene product. Cdc4p, is a 141-amino acid polypeptide that is similar in sequence to EF-hand proteins including myosin light chains, calmodulin, and troponin C. Two temperature-sensitive lethal alleles, cdc4-8 and cdc4-31, accumulate multiple nuclei and multiple improper F-actin rings and septa but fail to complete cytokinesis. Deletion of cdc4 also results in a lethal terminal phenotype characterized by multinucleate, elongated cells that fail to complete cytokinesis. Sequence comparisons suggest that Cdc4p may be a member of a new class of EF-hand proteins. Cdc4p localizes to a ringlike structure in the medial region of cells undergoing cytokinesis. Thus, Cdc4p appears to be an essential component of the F-actin contractile ring. We find that Cdc4 protein forms a complex with a 200-kD protein which can be cross-linked to UTP, a property common to myosin heavy chains. Together these results suggest that Cdc4p may be a novel myosin light chain." @default.
- W2015441623 created "2016-06-24" @default.
- W2015441623 creator A5015705751 @default.
- W2015441623 creator A5037696625 @default.
- W2015441623 creator A5038071740 @default.
- W2015441623 creator A5038921297 @default.
- W2015441623 creator A5066662711 @default.
- W2015441623 date "1995-08-01" @default.
- W2015441623 modified "2023-10-02" @default.
- W2015441623 title "Schizosaccharomyces pombe cdc4+ gene encodes a novel EF-hand protein essential for cytokinesis." @default.
- W2015441623 cites W1490400638 @default.
- W2015441623 cites W1510486443 @default.
- W2015441623 cites W1846585173 @default.
- W2015441623 cites W1963653582 @default.
- W2015441623 cites W1974777593 @default.
- W2015441623 cites W1975302750 @default.
- W2015441623 cites W1982301053 @default.
- W2015441623 cites W1984063704 @default.
- W2015441623 cites W1986506723 @default.
- W2015441623 cites W1992191014 @default.
- W2015441623 cites W1992274725 @default.
- W2015441623 cites W1992582635 @default.
- W2015441623 cites W1996084508 @default.
- W2015441623 cites W2009623058 @default.
- W2015441623 cites W2015292449 @default.
- W2015441623 cites W2015670559 @default.
- W2015441623 cites W2020058478 @default.
- W2015441623 cites W2023357066 @default.
- W2015441623 cites W2035383524 @default.
- W2015441623 cites W2049874412 @default.
- W2015441623 cites W2051165421 @default.
- W2015441623 cites W2062452071 @default.
- W2015441623 cites W2063826622 @default.
- W2015441623 cites W2068446924 @default.
- W2015441623 cites W2069873229 @default.
- W2015441623 cites W2140243527 @default.
- W2015441623 cites W2143763532 @default.
- W2015441623 cites W2147624113 @default.
- W2015441623 cites W2165780416 @default.
- W2015441623 cites W2166845172 @default.
- W2015441623 cites W2194986544 @default.
- W2015441623 cites W2403010495 @default.
- W2015441623 cites W4242292690 @default.
- W2015441623 cites W4253610379 @default.
- W2015441623 cites W4290198908 @default.
- W2015441623 cites W46922717 @default.
- W2015441623 cites W51833064 @default.
- W2015441623 cites W861725403 @default.
- W2015441623 doi "https://doi.org/10.1083/jcb.130.3.651" @default.
- W2015441623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2120525" @default.
- W2015441623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7622565" @default.
- W2015441623 hasPublicationYear "1995" @default.
- W2015441623 type Work @default.
- W2015441623 sameAs 2015441623 @default.
- W2015441623 citedByCount "153" @default.
- W2015441623 countsByYear W20154416232012 @default.
- W2015441623 countsByYear W20154416232013 @default.
- W2015441623 countsByYear W20154416232014 @default.
- W2015441623 countsByYear W20154416232015 @default.
- W2015441623 countsByYear W20154416232016 @default.
- W2015441623 countsByYear W20154416232017 @default.
- W2015441623 countsByYear W20154416232018 @default.
- W2015441623 countsByYear W20154416232019 @default.
- W2015441623 countsByYear W20154416232020 @default.
- W2015441623 countsByYear W20154416232021 @default.
- W2015441623 countsByYear W20154416232022 @default.
- W2015441623 countsByYear W20154416232023 @default.
- W2015441623 crossrefType "journal-article" @default.
- W2015441623 hasAuthorship W2015441623A5015705751 @default.
- W2015441623 hasAuthorship W2015441623A5037696625 @default.
- W2015441623 hasAuthorship W2015441623A5038071740 @default.
- W2015441623 hasAuthorship W2015441623A5038921297 @default.
- W2015441623 hasAuthorship W2015441623A5066662711 @default.
- W2015441623 hasBestOaLocation W20154416231 @default.
- W2015441623 hasConcept C104317684 @default.
- W2015441623 hasConcept C125705527 @default.
- W2015441623 hasConcept C134459356 @default.
- W2015441623 hasConcept C143065580 @default.
- W2015441623 hasConcept C1491633281 @default.
- W2015441623 hasConcept C162863750 @default.
- W2015441623 hasConcept C25602115 @default.
- W2015441623 hasConcept C2779429346 @default.
- W2015441623 hasConcept C45472230 @default.
- W2015441623 hasConcept C54355233 @default.
- W2015441623 hasConcept C6997183 @default.
- W2015441623 hasConcept C85813293 @default.
- W2015441623 hasConcept C86803240 @default.
- W2015441623 hasConcept C95444343 @default.
- W2015441623 hasConceptScore W2015441623C104317684 @default.
- W2015441623 hasConceptScore W2015441623C125705527 @default.
- W2015441623 hasConceptScore W2015441623C134459356 @default.
- W2015441623 hasConceptScore W2015441623C143065580 @default.
- W2015441623 hasConceptScore W2015441623C1491633281 @default.
- W2015441623 hasConceptScore W2015441623C162863750 @default.
- W2015441623 hasConceptScore W2015441623C25602115 @default.
- W2015441623 hasConceptScore W2015441623C2779429346 @default.
- W2015441623 hasConceptScore W2015441623C45472230 @default.
- W2015441623 hasConceptScore W2015441623C54355233 @default.