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- W2015442199 abstract "Objective By the year of 2020, India will have the largest cardiovascular diseases (CVD) burden in the world. Hypertension is one of the important risk factor of CVD. In India, a large group of people suffer with hypertension. Endothelial dysfunction is associated with most forms of CVD including hypertension, coronary artery disease and heart failure etc. Oxidative stress is involved in the pathogenesis of a wide range of CVD including hypertension. There is growing evidence that endothelium derived cell adhesion molecules play crucial role in the regulation of blood pressure. Endothelium is the target for prevention of cardiovascular disorders. Keeping this in view, we aimed at assessing the relationship between essential hypertension, cell adhesion molecules and oxidative stress. Methods Various parameters for oxidative stress and cell adhesion molecules were determined using standard procedures and R&D Elisa kits, respectively. Results The increase in oxidative stress might be contributed by decline in the levels of superoxide dismutase and catalase activity and lower levels of nitric oxide and higher levels of malondialdehyde in patients with essential hypertension as compared to normal healthy individuals. The levels of E-selectin and S VCAM-1 in patients were higher as compared to controls. Conclusion This study, first of its kind, from India suggested that oxidative stress is prevalent in patients with essential hypertension at lower age group. Nitric oxide emerged as protective factor against the disease. Oxidative stress and cell adhesion molecules emerged as key risk factors for essential hypertension." @default.
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- W2015442199 date "2009-10-01" @default.
- W2015442199 modified "2023-09-24" @default.
- W2015442199 title "Role of cell adhesion molecules and oxidative stress in essential hypertension in Asian Indians" @default.
- W2015442199 doi "https://doi.org/10.1016/j.ijcard.2009.09.177" @default.
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