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• W2015446265 abstract "Les effets de l'amrinone sont évalués en présence d'un bas débit cardiaque après remplacement valvulaire mitral dans une étude prospective ouverte incluant 12 adultes. En moyenne, les patients reçoivent 1,5 mg · kg−1 d'amrinone durant la première heure, suivi d'une perfusion continue de 9 ± 3 μg · kg−1 · min−1 (moyenne ± SD) pendant au moins 24 heures. A la première heure, la pression artérielle systolique, l'index cardiaque, l'index systolique et le travail systolique ventriculaire gauche s'accroissent respectivement de 22, 42, 23 et 47 % et la pression capillaire pulmonaire baisse de 27 %. La fréquence cardiaque augmente et les résistances vasculaires systémiques diminuent de manière non significative. La pression auriculaire droite, le travail systolique ventriculaire droit, les pressions et résistances artérielles pulmonaires ne sont pas modifiées. Ces effets se maintiennent à la 48e heure de traitement. L'amrinone est remplacée trois fois par un sympathomimétique. Elle apparaît comme un agent inotrope capable d'augmenter le plus souvent la performance ventriculaire gauche avec peu d'effets sur le ventricule droit pour ce type de patient. The efficacy of amrinone was assessed in the treatment of low cardiac output states occuring within 24 h after mitral valve replacement in an open prospective trial. It included 7 women and 5 men, aged 58 ± 10 years. Four patients had also had simultaneous aortic valve replacement. Patients entered in the study if their cardiac index (CI) remained < 2.21 · min−1 · m−2 after pulmonary wedged pressure (Ppw) had been increased to at least 15 mmHg, the patient having a temperature > 36 °C. Amrinone was given so as to increase Cl by at least 30 % and to decrease Ppw by at least 30 %. Patients were given a mean of 1.5 mg · kg−1 amrinone during the first hour, followed by a constant rate infusion of 9 ± 3 μg · kg−1 · min−1 over at least 24 h. The usual haemodynamic parameters were measured and calculated before giving amrinone, and after 1, 3, 6, 24, and 48 h. After 1 h of treatment, systolic arterial pressure, cardiac index, systolic index and left ventricular stroke work increased by 22, 42, 23 and 47 % respectively, whilst Ppw decreased by 27 % (p < 0.01). Heart rate rose and systemic vascular resistance decreased but not significantly. Right atrial pressure, right ventricular stroke work, pulmonary artery pressure and pulmonary vascular resistance did not change. These effects were all maintained throughout the 48 h infusion. Amrinone had to be replaced by another agent (a β-agonist) in 3 cases because of arrhythmia, lack of efficacy or thrombocytopaenia. In this setting, amrinone increased left ventricular performance with little effect on the right ventricule." @default.
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• W2015446265 date "1991-01-01" @default.
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• W2015446265 title "Effets hémodynamiques de l'amrinone dans le bas débit cardiaque après remplacement valvulaire mitral" @default.
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• W2015446265 doi "https://doi.org/10.1016/s0750-7658(05)80450-2" @default.
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