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- W2015447772 abstract "Despite considerable progress being made in understanding pancreatic cancer (PC) pathogenesis, it still remains the 10th most often diagnosed malignancy in the world and 4th leading cause of cancer related deaths in the United States with a five year survival rate of only 6%. The aggressive nature, lack of early diagnostic and prognostic markers, late clinical presentation, and limited efficacy of existing treatment regimens make PC a lethal cancer with high mortality and poor prognosis. Therefore, novel reliable biomarkers and molecular targets are urgently needed to combat this deadly disease. MicroRNAs (miRNAs) are short (19-24 nucleotides) non-coding RNA molecules implicated in the regulation of gene expression at post-transcriptional level and play significant roles in various physiological and pathological conditions. Aberrant expression of miRNAs has been reported in several cancers including PC and is implicated in PC pathogenesis and progression, suggesting their utility in diagnosis, prognosis and therapy. In this review, we summarize the role of several miRNAs that regulate various oncogenes (KRAS) and tumor suppressor genes (p53, p16, SMAD4, etc.) involved in PC development, their prospective roles as diagnostic and prognostic markers and as a therapeutic targets." @default.
- W2015447772 created "2016-06-24" @default.
- W2015447772 creator A5002662464 @default.
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- W2015447772 creator A5036384868 @default.
- W2015447772 creator A5059751626 @default.
- W2015447772 creator A5085256777 @default.
- W2015447772 date "2015-01-01" @default.
- W2015447772 modified "2023-10-15" @default.
- W2015447772 title "Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer" @default.
- W2015447772 cites W144423133 @default.
- W2015447772 cites W1551232230 @default.
- W2015447772 cites W1561536568 @default.
- W2015447772 cites W1563316806 @default.
- W2015447772 cites W1580395275 @default.
- W2015447772 cites W1588962899 @default.
- W2015447772 cites W1955920682 @default.
- W2015447772 cites W1963952972 @default.
- W2015447772 cites W1965641017 @default.
- W2015447772 cites W1966163762 @default.
- W2015447772 cites W1969669359 @default.
- W2015447772 cites W1971836576 @default.
- W2015447772 cites W1972551831 @default.
- W2015447772 cites W1975332766 @default.
- W2015447772 cites W1975398023 @default.
- W2015447772 cites W1975412433 @default.
- W2015447772 cites W1975865328 @default.
- W2015447772 cites W1976120046 @default.
- W2015447772 cites W1976324983 @default.
- W2015447772 cites W1976549493 @default.
- W2015447772 cites W1978730308 @default.
- W2015447772 cites W1979673666 @default.
- W2015447772 cites W1980387419 @default.
- W2015447772 cites W1981337389 @default.
- W2015447772 cites W1981889510 @default.
- W2015447772 cites W1983767545 @default.
- W2015447772 cites W1985960583 @default.
- W2015447772 cites W1986176461 @default.
- W2015447772 cites W1986903527 @default.
- W2015447772 cites W1992303379 @default.
- W2015447772 cites W1992638032 @default.
- W2015447772 cites W1992995822 @default.
- W2015447772 cites W1993399909 @default.
- W2015447772 cites W1993916353 @default.
- W2015447772 cites W1994645662 @default.
- W2015447772 cites W1994724955 @default.
- W2015447772 cites W1995399248 @default.
- W2015447772 cites W1995624011 @default.
- W2015447772 cites W1996094302 @default.
- W2015447772 cites W1997939286 @default.
- W2015447772 cites W1999942858 @default.
- W2015447772 cites W2000227837 @default.
- W2015447772 cites W2000961142 @default.
- W2015447772 cites W2000982792 @default.
- W2015447772 cites W2001911979 @default.
- W2015447772 cites W2002355858 @default.
- W2015447772 cites W2002995168 @default.
- W2015447772 cites W2003334487 @default.
- W2015447772 cites W2004256614 @default.
- W2015447772 cites W2004293514 @default.
- W2015447772 cites W2004588189 @default.
- W2015447772 cites W2004791359 @default.
- W2015447772 cites W2005101609 @default.
- W2015447772 cites W2005109475 @default.
- W2015447772 cites W2005880821 @default.
- W2015447772 cites W2005894707 @default.
- W2015447772 cites W2006173503 @default.
- W2015447772 cites W2006797972 @default.
- W2015447772 cites W2010247154 @default.
- W2015447772 cites W2010591782 @default.
- W2015447772 cites W2011687097 @default.
- W2015447772 cites W2013064309 @default.
- W2015447772 cites W2013721931 @default.
- W2015447772 cites W2013842709 @default.
- W2015447772 cites W2014200421 @default.
- W2015447772 cites W2014783179 @default.
- W2015447772 cites W2014946489 @default.
- W2015447772 cites W2017449972 @default.
- W2015447772 cites W2017905687 @default.
- W2015447772 cites W2019517037 @default.
- W2015447772 cites W2019867275 @default.
- W2015447772 cites W2020080445 @default.
- W2015447772 cites W2022192230 @default.
- W2015447772 cites W2022687771 @default.
- W2015447772 cites W2023987874 @default.
- W2015447772 cites W2026051181 @default.
- W2015447772 cites W2026468262 @default.
- W2015447772 cites W2026595595 @default.
- W2015447772 cites W2030003939 @default.
- W2015447772 cites W2030613016 @default.
- W2015447772 cites W2031252637 @default.
- W2015447772 cites W2031475327 @default.
- W2015447772 cites W2032125405 @default.
- W2015447772 cites W2033320521 @default.
- W2015447772 cites W2034181626 @default.
- W2015447772 cites W2034269086 @default.
- W2015447772 cites W2034760388 @default.