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- W2015448906 abstract "Acromegaly is a chronic disease caused by overproduction of growth hormone, in most cases due to excessive secretion from a pituitary adenoma [1, 2]. The incidence of acromegaly is approximately 5 cases per million per year, and the prevalence is estimated to be about 60 cases per million [3]. Growth hormone (GH) induces the synthesis of insulin-like growth factor-1 (IGF-1), which leads to severe metabolic complications resulting in significant morbidity and mortality [2, 4, 5]. It has been suggested that the mortality associated with acromegaly is at least two-fold higher compared to the general population, especially due to the higher prevalence of hypertension, diabetes, cardiovascular complications, and sleep apnoea, and it may be reduced after sufficient control of GH and IGF-1 levels [4, 6, 7]. Approximately 70% of acromegalic subjects have macroadenomas, and the majority of them will not be cured by surgery alone and will require adjuvant medical therapy or radiotherapy [2, 5, 8]." @default.
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- W2015448906 date "2016-01-01" @default.
- W2015448906 modified "2023-10-15" @default.
- W2015448906 title "Soluble Klotho protein as a novel serum biomarker in patients with acromegaly" @default.
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- W2015448906 doi "https://doi.org/10.5114/aoms.2014.45050" @default.
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