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- W2015451669 abstract "To determine whether expansion of CAG repeats in exon 1 of the androgen receptor is correlated with impaired spermatogenesis in patients with male idiopathic infertility.A retrospective study.Medical school in Besançon, France.Thirty-seven infertile patients with azoospermia or oligospermia and 50 fertile controls.History, physical, hormonal assays, semen analysis, and collection of blood samples in order to study the androgen receptor's gene.Blood samples were collected from each infertile patient and control. The length of the CAG repeat segment was evaluated by using polymerase chain reaction (PCR) electrophoresis in exon 1 and PCR single-strand conformation polymorphism in exons 2-8.The mean length of the CAG repeats was significantly different between infertile and fertile patients (23.91 +/- 0.5 vs. 22.20 +/- 0.4). No mutation was detected in exons 2-8 of the androgen receptor gene in infertile patients.Expansion of the CAG repeat segment of the androgen receptor is correlated with male idiopathic infertility. The number of CAG repeats may therefore have a modulatory effect on normal androgen receptor function." @default.
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- W2015451669 date "2001-10-01" @default.
- W2015451669 modified "2023-10-13" @default.
- W2015451669 title "Relationship between expansion of the CAG repeat in exon 1 of the androgen receptor gene and idiopathic male infertility" @default.
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- W2015451669 doi "https://doi.org/10.1016/s0015-0282(01)01987-2" @default.
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