Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015451891> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2015451891 endingPage "1664" @default.
- W2015451891 startingPage "1656" @default.
- W2015451891 abstract "With the exception of its two aromatic rings and basic nitrogen atom, 9-(aminomethyl)-9,10-dihydroanthracene (AMDA; 1) is remarkably devoid of the pharmacophore features usually associated with high-affinity receptor ligands such as the heteroatom hydrogen bonding features of the endogenous ligand serotonin. AMDA does contain a phenylethylamine skeleton within a tricyclic ring system, and the presence of the second aromatic group is necessary for optimal receptor affinity. The structural requirements for the binding of AMDA at 5-HT(2A) receptors were investigated with respect to the geometric relationship between the two aromatic rings. It appears that the geometry of the AMDA parent is in the optimal range for fold angle between aromatic moieties. Evaluation of conformationally constrained derivatives of AMDA suggests that a chain extended trans, gauche form is most likely responsible for high affinity." @default.
- W2015451891 created "2016-06-24" @default.
- W2015451891 creator A5001261077 @default.
- W2015451891 creator A5007856961 @default.
- W2015451891 creator A5009073724 @default.
- W2015451891 creator A5055381834 @default.
- W2015451891 creator A5058910529 @default.
- W2015451891 creator A5087801455 @default.
- W2015451891 date "2002-03-15" @default.
- W2015451891 modified "2023-09-28" @default.
- W2015451891 title "Geometry−Affinity Relationships of the Selective Serotonin Receptor Ligand 9-(Aminomethyl)-9,10-dihydroanthracene" @default.
- W2015451891 cites W1972962890 @default.
- W2015451891 cites W1978432696 @default.
- W2015451891 cites W1986778740 @default.
- W2015451891 cites W2016608723 @default.
- W2015451891 cites W2022993336 @default.
- W2015451891 cites W2057228883 @default.
- W2015451891 cites W2068039801 @default.
- W2015451891 cites W2076641965 @default.
- W2015451891 cites W2081976710 @default.
- W2015451891 cites W2084077113 @default.
- W2015451891 cites W2323299761 @default.
- W2015451891 cites W2323623905 @default.
- W2015451891 cites W2324367554 @default.
- W2015451891 cites W2335272231 @default.
- W2015451891 cites W2949232632 @default.
- W2015451891 cites W2952422754 @default.
- W2015451891 doi "https://doi.org/10.1021/jm010354g" @default.
- W2015451891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11931619" @default.
- W2015451891 hasPublicationYear "2002" @default.
- W2015451891 type Work @default.
- W2015451891 sameAs 2015451891 @default.
- W2015451891 citedByCount "15" @default.
- W2015451891 countsByYear W20154518912015 @default.
- W2015451891 countsByYear W20154518912016 @default.
- W2015451891 countsByYear W20154518912019 @default.
- W2015451891 countsByYear W20154518912020 @default.
- W2015451891 countsByYear W20154518912021 @default.
- W2015451891 countsByYear W20154518912023 @default.
- W2015451891 crossrefType "journal-article" @default.
- W2015451891 hasAuthorship W2015451891A5001261077 @default.
- W2015451891 hasAuthorship W2015451891A5007856961 @default.
- W2015451891 hasAuthorship W2015451891A5009073724 @default.
- W2015451891 hasAuthorship W2015451891A5055381834 @default.
- W2015451891 hasAuthorship W2015451891A5058910529 @default.
- W2015451891 hasAuthorship W2015451891A5087801455 @default.
- W2015451891 hasConcept C112887158 @default.
- W2015451891 hasConcept C116569031 @default.
- W2015451891 hasConcept C170493617 @default.
- W2015451891 hasConcept C178790620 @default.
- W2015451891 hasConcept C185592680 @default.
- W2015451891 hasConcept C192386470 @default.
- W2015451891 hasConcept C20950531 @default.
- W2015451891 hasConcept C2780378348 @default.
- W2015451891 hasConcept C2781081902 @default.
- W2015451891 hasConcept C32909587 @default.
- W2015451891 hasConcept C55493867 @default.
- W2015451891 hasConcept C56173144 @default.
- W2015451891 hasConcept C71240020 @default.
- W2015451891 hasConceptScore W2015451891C112887158 @default.
- W2015451891 hasConceptScore W2015451891C116569031 @default.
- W2015451891 hasConceptScore W2015451891C170493617 @default.
- W2015451891 hasConceptScore W2015451891C178790620 @default.
- W2015451891 hasConceptScore W2015451891C185592680 @default.
- W2015451891 hasConceptScore W2015451891C192386470 @default.
- W2015451891 hasConceptScore W2015451891C20950531 @default.
- W2015451891 hasConceptScore W2015451891C2780378348 @default.
- W2015451891 hasConceptScore W2015451891C2781081902 @default.
- W2015451891 hasConceptScore W2015451891C32909587 @default.
- W2015451891 hasConceptScore W2015451891C55493867 @default.
- W2015451891 hasConceptScore W2015451891C56173144 @default.
- W2015451891 hasConceptScore W2015451891C71240020 @default.
- W2015451891 hasIssue "8" @default.
- W2015451891 hasLocation W20154518911 @default.
- W2015451891 hasLocation W20154518912 @default.
- W2015451891 hasOpenAccess W2015451891 @default.
- W2015451891 hasPrimaryLocation W20154518911 @default.
- W2015451891 hasRelatedWork W1268251808 @default.
- W2015451891 hasRelatedWork W1522940047 @default.
- W2015451891 hasRelatedWork W1982782412 @default.
- W2015451891 hasRelatedWork W2015451891 @default.
- W2015451891 hasRelatedWork W2061544958 @default.
- W2015451891 hasRelatedWork W2070825201 @default.
- W2015451891 hasRelatedWork W2090700225 @default.
- W2015451891 hasRelatedWork W235096659 @default.
- W2015451891 hasRelatedWork W2940853498 @default.
- W2015451891 hasRelatedWork W3018455925 @default.
- W2015451891 hasVolume "45" @default.
- W2015451891 isParatext "false" @default.
- W2015451891 isRetracted "false" @default.
- W2015451891 magId "2015451891" @default.
- W2015451891 workType "article" @default.