FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015452592> ?p ?o ?g. }

• W2015452592 endingPage "36098" @default.
• W2015452592 startingPage "36091" @default.
• W2015452592 abstract "The nuclear receptors liver X receptor (LXR) alpha and LXRbeta serve as oxysterol receptors and regulate the expression of genes involved in lipid metabolism. LXR activation induces the expression of ATP-binding cassette (ABC) transporters, such as ABCG5 and ABCG8, which inhibit intestinal absorption of cholesterol and phytosterols. Although several synthetic LXR agonists have been generated, these compounds have limited clinical application, because they cause hypertriglycemia by inducing the expression of lipogenic genes in the liver. We synthesized derivatives of phytosterols and found some of them to act as LXR agonists. Among them, YT-32 [(22E)-ergost-22-ene-1alpha,3beta-diol], which is related to ergosterol and brassicasterol, is the most potent LXR agonist. YT-32 directly bound to LXRalpha and LXRbeta and induced the interaction of LXRalpha with cofactors, such as steroid receptor coactivator-1, as effectively as the natural ligands, 22(R)-hydroxycholesterol and 24(S),25-epoxycholesterol. Although the nonsteroidal synthetic LXR agonist T0901317 induced the expression of intestinal ABC transporters and liver lipogenic genes, oral administration of YT-32 selectively activated intestinal ABC transporters in mice. Unlike T0901317 treatment, YT-32 inhibited intestinal cholesterol absorption without increasing plasma triglyceride levels. The phytosterol-derived LXR agonist YT-32 might selectively modulate intestinal cholesterol metabolism." @default.
• W2015452592 created "2016-06-24" @default.
• W2015452592 creator A5000887170 @default.
• W2015452592 creator A5037246488 @default.
• W2015452592 creator A5047196134 @default.
• W2015452592 creator A5074067640 @default.
• W2015452592 creator A5084885924 @default.
• W2015452592 creator A5043784698 @default.
• W2015452592 date "2003-09-01" @default.
• W2015452592 modified "2023-09-26" @default.
• W2015452592 title "Induction of Intestinal ATP-binding Cassette Transporters by a Phytosterol-derived Liver X Receptor Agonist" @default.
• W2015452592 cites W1501286679 @default.
• W2015452592 cites W1967286688 @default.
• W2015452592 cites W1973243569 @default.
• W2015452592 cites W1982715024 @default.
• W2015452592 cites W1996168740 @default.
• W2015452592 cites W2000577172 @default.
• W2015452592 cites W2000581994 @default.
• W2015452592 cites W2001332055 @default.
• W2015452592 cites W2008450021 @default.
• W2015452592 cites W2021206718 @default.
• W2015452592 cites W2024851295 @default.
• W2015452592 cites W2027663543 @default.
• W2015452592 cites W2034790783 @default.
• W2015452592 cites W2040417680 @default.
• W2015452592 cites W2046658442 @default.
• W2015452592 cites W2046659875 @default.
• W2015452592 cites W2053581007 @default.
• W2015452592 cites W2059367957 @default.
• W2015452592 cites W2063612133 @default.
• W2015452592 cites W2068458442 @default.
• W2015452592 cites W2082508806 @default.
• W2015452592 cites W2085909854 @default.
• W2015452592 cites W2086317930 @default.
• W2015452592 cites W2095786854 @default.
• W2015452592 cites W2099378835 @default.
• W2015452592 cites W2108987650 @default.
• W2015452592 cites W2112632255 @default.
• W2015452592 cites W2119133998 @default.
• W2015452592 cites W2129937334 @default.
• W2015452592 cites W2135007868 @default.
• W2015452592 cites W2137188051 @default.
• W2015452592 cites W2153673003 @default.
• W2015452592 cites W2156575042 @default.
• W2015452592 cites W2157817725 @default.
• W2015452592 cites W2159332620 @default.
• W2015452592 cites W2165104851 @default.
• W2015452592 cites W2169319034 @default.
• W2015452592 cites W2172132693 @default.
• W2015452592 cites W4244071318 @default.
• W2015452592 cites W4247935329 @default.
• W2015452592 cites W4251360714 @default.
• W2015452592 doi "https://doi.org/10.1074/jbc.m304153200" @default.
• W2015452592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12847102" @default.
• W2015452592 hasPublicationYear "2003" @default.
• W2015452592 type Work @default.
• W2015452592 sameAs 2015452592 @default.
• W2015452592 citedByCount "186" @default.
• W2015452592 countsByYear W20154525922012 @default.
• W2015452592 countsByYear W20154525922013 @default.
• W2015452592 countsByYear W20154525922014 @default.
• W2015452592 countsByYear W20154525922015 @default.
• W2015452592 countsByYear W20154525922016 @default.
• W2015452592 countsByYear W20154525922017 @default.
• W2015452592 countsByYear W20154525922018 @default.
• W2015452592 countsByYear W20154525922019 @default.
• W2015452592 countsByYear W20154525922020 @default.
• W2015452592 countsByYear W20154525922021 @default.
• W2015452592 countsByYear W20154525922022 @default.
• W2015452592 countsByYear W20154525922023 @default.
• W2015452592 crossrefType "journal-article" @default.
• W2015452592 hasAuthorship W2015452592A5000887170 @default.
• W2015452592 hasAuthorship W2015452592A5037246488 @default.
• W2015452592 hasAuthorship W2015452592A5043784698 @default.
• W2015452592 hasAuthorship W2015452592A5047196134 @default.
• W2015452592 hasAuthorship W2015452592A5074067640 @default.
• W2015452592 hasAuthorship W2015452592A5084885924 @default.
• W2015452592 hasBestOaLocation W20154525921 @default.
• W2015452592 hasConcept C104317684 @default.
• W2015452592 hasConcept C149011108 @default.
• W2015452592 hasConcept C167400880 @default.
• W2015452592 hasConcept C170493617 @default.
• W2015452592 hasConcept C185592680 @default.
• W2015452592 hasConcept C2777704780 @default.
• W2015452592 hasConcept C2778938600 @default.
• W2015452592 hasConcept C44312359 @default.
• W2015452592 hasConcept C55493867 @default.
• W2015452592 hasConcept C63932345 @default.
• W2015452592 hasConcept C76591681 @default.
• W2015452592 hasConcept C77445288 @default.
• W2015452592 hasConcept C86339819 @default.
• W2015452592 hasConcept C86803240 @default.
• W2015452592 hasConceptScore W2015452592C104317684 @default.
• W2015452592 hasConceptScore W2015452592C149011108 @default.
• W2015452592 hasConceptScore W2015452592C167400880 @default.
• W2015452592 hasConceptScore W2015452592C170493617 @default.
• W2015452592 hasConceptScore W2015452592C185592680 @default.
• W2015452592 hasConceptScore W2015452592C2777704780 @default.

• next