FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015452620> ?p ?o ?g. }

• W2015452620 endingPage "879" @default.
• W2015452620 startingPage "871" @default.
• W2015452620 abstract "In a previous study, we found that the antinociceptive effect of IT-administered morphine on the tail-flick (TF) reflex of rats was potentiated within 1 day after spinal transection. This suggested that the analgesic effect of spinal morphine in the intact animal was tonically suppressed, presumably by the release of a transmitter(s) from descending supraspinal pathway(s), and that the potency of IT morphine was increased because these inputs were removed by spinalization. Because spinally projecting serotonin [5-hydroxytryptamine (5-HT)] fibers are known to be involved in modulating nociception at this site, the present studies examined the possibility that 5-HT might be the proposed antiopiate at the spinal cord. Separate groups of intact and spinal rats were pretested on the TF and then injected IT with either morphine (intact: 0.25-5.0 micrograms, spinal: 0.0312-0.5 microgram) or 5-HT (1-200 micrograms), or combinations of these two agents, in a single solution. All rats were then retested 15 min later and the difference in latency was used to compare the effect of these treatments. The results confirmed that the antinociceptive effect of IT morphine was significantly increased by spinalization, whereas the antinociceptive effect of 5-HT was essentially abolished. In intact rats, morphine-induced analgesia was potentiated by a low (10 micrograms) dose of 5-HT but not by higher doses. However, in the spinal rat morphine-induced antinociception was antagonized by the same (10 micrograms) dose. The data suggest that IT 5-HT promotes antinociception in intact rats but acts pro-nociceptively in spinal rats.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2015452620 created "2016-06-24" @default.
• W2015452620 creator A5023784145 @default.
• W2015452620 date "1993-08-01" @default.
• W2015452620 modified "2023-09-27" @default.
• W2015452620 title "Intrathecal coadministration of serotonin and morphine differentially modulates the tail-flick reflex of intact and spinal rats" @default.
• W2015452620 cites W1559977040 @default.
• W2015452620 cites W1967498912 @default.
• W2015452620 cites W1968043085 @default.
• W2015452620 cites W1969416157 @default.
• W2015452620 cites W1972146001 @default.
• W2015452620 cites W1973566592 @default.
• W2015452620 cites W1973913858 @default.
• W2015452620 cites W1976166428 @default.
• W2015452620 cites W1986139523 @default.
• W2015452620 cites W1989943762 @default.
• W2015452620 cites W1993090680 @default.
• W2015452620 cites W1993267487 @default.
• W2015452620 cites W1994278254 @default.
• W2015452620 cites W1994653605 @default.
• W2015452620 cites W2000609341 @default.
• W2015452620 cites W2001280030 @default.
• W2015452620 cites W2002255891 @default.
• W2015452620 cites W2002515362 @default.
• W2015452620 cites W2005764582 @default.
• W2015452620 cites W2007474835 @default.
• W2015452620 cites W2013720825 @default.
• W2015452620 cites W2013959186 @default.
• W2015452620 cites W2017082899 @default.
• W2015452620 cites W2017477399 @default.
• W2015452620 cites W2018230194 @default.
• W2015452620 cites W2019369751 @default.
• W2015452620 cites W2020860457 @default.
• W2015452620 cites W2020925449 @default.
• W2015452620 cites W2031577632 @default.
• W2015452620 cites W2034862541 @default.
• W2015452620 cites W2036526792 @default.
• W2015452620 cites W2037951668 @default.
• W2015452620 cites W2040294385 @default.
• W2015452620 cites W2041165143 @default.
• W2015452620 cites W2046396235 @default.
• W2015452620 cites W2046879601 @default.
• W2015452620 cites W2054088778 @default.
• W2015452620 cites W2056271203 @default.
• W2015452620 cites W2057615421 @default.
• W2015452620 cites W2057899313 @default.
• W2015452620 cites W2059084864 @default.
• W2015452620 cites W2061296589 @default.
• W2015452620 cites W2065754197 @default.
• W2015452620 cites W2068192220 @default.
• W2015452620 cites W2068273954 @default.
• W2015452620 cites W2071822143 @default.
• W2015452620 cites W2073987850 @default.
• W2015452620 cites W2074160789 @default.
• W2015452620 cites W2075243069 @default.
• W2015452620 cites W2078056215 @default.
• W2015452620 cites W2080055024 @default.
• W2015452620 cites W2080108774 @default.
• W2015452620 cites W2084840452 @default.
• W2015452620 cites W2090090538 @default.
• W2015452620 cites W2090334248 @default.
• W2015452620 cites W2094785538 @default.
• W2015452620 cites W2112481252 @default.
• W2015452620 cites W2146549635 @default.
• W2015452620 cites W2742181128 @default.
• W2015452620 doi "https://doi.org/10.1016/0091-3057(93)90134-f" @default.
• W2015452620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8415826" @default.
• W2015452620 hasPublicationYear "1993" @default.
• W2015452620 type Work @default.
• W2015452620 sameAs 2015452620 @default.
• W2015452620 citedByCount "12" @default.
• W2015452620 countsByYear W20154526202016 @default.
• W2015452620 countsByYear W20154526202021 @default.
• W2015452620 crossrefType "journal-article" @default.
• W2015452620 hasAuthorship W2015452620A5023784145 @default.
• W2015452620 hasConcept C118552586 @default.
• W2015452620 hasConcept C126322002 @default.
• W2015452620 hasConcept C134018914 @default.
• W2015452620 hasConcept C15490471 @default.
• W2015452620 hasConcept C170493617 @default.
• W2015452620 hasConcept C185592680 @default.
• W2015452620 hasConcept C195512701 @default.
• W2015452620 hasConcept C202751555 @default.
• W2015452620 hasConcept C2775864247 @default.
• W2015452620 hasConcept C2777389121 @default.
• W2015452620 hasConcept C2780775167 @default.
• W2015452620 hasConcept C2780820201 @default.
• W2015452620 hasConcept C42219234 @default.
• W2015452620 hasConcept C52396799 @default.
• W2015452620 hasConcept C529278444 @default.
• W2015452620 hasConcept C55493867 @default.
• W2015452620 hasConcept C57992300 @default.
• W2015452620 hasConcept C71924100 @default.
• W2015452620 hasConcept C83974742 @default.
• W2015452620 hasConcept C98274493 @default.
• W2015452620 hasConceptScore W2015452620C118552586 @default.
• W2015452620 hasConceptScore W2015452620C126322002 @default.
• W2015452620 hasConceptScore W2015452620C134018914 @default.

• next