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• W2015453062 endingPage "7350" @default.
• W2015453062 startingPage "7350" @default.
• W2015453062 abstract "Purpose.: This study represents a first step toward the evaluation of possible compositional differences in meibum from normal donors (Mn) and donors with meibomian gland dysfunction (Md) by 1H-NMR spectroscopy. The results highlight the applicability of 1H-NMR spectroscopy for the quantitative analysis of waxes, cholesteryl esters, and glycerides in meibum lipid (ML). Methods.: Meibum was obtained from 41 normal donors and 51 donors with meibomian gland dysfunction (MGD). 1H-NMR spectroscopy was used to quantify the amount of waxes, glycerides, and cholesteryl esters in human meibum. Results.: The relative amount of cholesteryl esters in Mn increased with age and was 40% (P < 0.05) lower in Md. Interestingly, the relative levels of cholesteryl esters in infant meibum were comparable to those in Md. The relative amounts of glycerides were not affected significantly by age or MGD. Conclusions.: The changes in cholesteryl ester could be used as a molecular marker for MGD and could potentially be applied to follow the efficacy of drug therapy in the treatment of MGD. The similarity of the levels of cholesteryl esters in infant meibum and Md suggests that the relative amounts of these meibum components alone are unlikely to be responsible for the increased stability of the infant tear film and decreased stability of the tear film with MGD. This study reveals the complexity of human MLs and the changes that occur with age and disease. Understanding the factors that lead to such variations is of utmost relevance in the design of effective therapies." @default.
• W2015453062 created "2016-06-24" @default.
• W2015453062 creator A5002638584 @default.
• W2015453062 creator A5031315736 @default.
• W2015453062 creator A5031603403 @default.
• W2015453062 creator A5052026761 @default.
• W2015453062 creator A5089111825 @default.
• W2015453062 date "2011-09-20" @default.
• W2015453062 modified "2023-10-16" @default.
• W2015453062 title "Analysis of the Composition of Lipid in Human Meibum from Normal Infants, Children, Adolescents, Adults, and Adults with Meibomian Gland Dysfunction Using¹H-NMR Spectroscopy" @default.
• W2015453062 cites W100744059 @default.
• W2015453062 cites W103761139 @default.
• W2015453062 cites W110513267 @default.
• W2015453062 cites W152407597 @default.
• W2015453062 cites W1575515320 @default.
• W2015453062 cites W177996137 @default.
• W2015453062 cites W1965314518 @default.
• W2015453062 cites W1966133493 @default.
• W2015453062 cites W1966308680 @default.
• W2015453062 cites W1970505240 @default.
• W2015453062 cites W1970785194 @default.
• W2015453062 cites W1976571829 @default.
• W2015453062 cites W1978846384 @default.
• W2015453062 cites W1986170687 @default.
• W2015453062 cites W1986303388 @default.
• W2015453062 cites W1986628104 @default.
• W2015453062 cites W1988108903 @default.
• W2015453062 cites W1988161999 @default.
• W2015453062 cites W1988424689 @default.
• W2015453062 cites W1988927261 @default.
• W2015453062 cites W1993433856 @default.
• W2015453062 cites W1995031501 @default.
• W2015453062 cites W1998448125 @default.
• W2015453062 cites W1998468408 @default.
• W2015453062 cites W1999869602 @default.
• W2015453062 cites W1999940631 @default.
• W2015453062 cites W2000464464 @default.
• W2015453062 cites W2000868500 @default.
• W2015453062 cites W2003800490 @default.
• W2015453062 cites W200518479 @default.
• W2015453062 cites W2013507577 @default.
• W2015453062 cites W2014337703 @default.
• W2015453062 cites W2023328409 @default.
• W2015453062 cites W2024611006 @default.
• W2015453062 cites W2024971484 @default.
• W2015453062 cites W2025634355 @default.
• W2015453062 cites W2026838411 @default.
• W2015453062 cites W2031680154 @default.
• W2015453062 cites W2035133926 @default.
• W2015453062 cites W2035297037 @default.
• W2015453062 cites W2036711210 @default.
• W2015453062 cites W2038338078 @default.
• W2015453062 cites W2039169328 @default.
• W2015453062 cites W2042919100 @default.
• W2015453062 cites W2043711203 @default.
• W2015453062 cites W2045512526 @default.
• W2015453062 cites W2046218673 @default.
• W2015453062 cites W2048699203 @default.
• W2015453062 cites W2051054352 @default.
• W2015453062 cites W2052060765 @default.
• W2015453062 cites W2056036829 @default.
• W2015453062 cites W2060113246 @default.
• W2015453062 cites W2060230214 @default.
• W2015453062 cites W2065664870 @default.
• W2015453062 cites W2069404307 @default.
• W2015453062 cites W2070002573 @default.
• W2015453062 cites W2073684335 @default.
• W2015453062 cites W2076829621 @default.
• W2015453062 cites W2079375487 @default.
• W2015453062 cites W2079803088 @default.
• W2015453062 cites W2080993323 @default.
• W2015453062 cites W2087116880 @default.
• W2015453062 cites W2087166815 @default.
• W2015453062 cites W2087371805 @default.
• W2015453062 cites W2089250400 @default.
• W2015453062 cites W2093520791 @default.
• W2015453062 cites W2100925437 @default.
• W2015453062 cites W2101023960 @default.
• W2015453062 cites W2112327432 @default.
• W2015453062 cites W2112585829 @default.
• W2015453062 cites W2123788993 @default.
• W2015453062 cites W2123866715 @default.
• W2015453062 cites W2135702688 @default.
• W2015453062 cites W2145204801 @default.
• W2015453062 cites W2147916356 @default.
• W2015453062 cites W2155744199 @default.
• W2015453062 cites W2168392681 @default.
• W2015453062 cites W2170371277 @default.
• W2015453062 cites W2228011003 @default.
• W2015453062 cites W23126284 @default.
• W2015453062 cites W2318799310 @default.
• W2015453062 cites W32439334 @default.
• W2015453062 cites W37688013 @default.
• W2015453062 cites W43856797 @default.
• W2015453062 cites W77534462 @default.
• W2015453062 cites W1536864657 @default.
• W2015453062 cites W2842556333 @default.
• W2015453062 doi "https://doi.org/10.1167/iovs.11-7391" @default.

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