FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015453107> ?p ?o ?g. }

• W2015453107 endingPage "21" @default.
• W2015453107 startingPage "13" @default.
• W2015453107 abstract "Cultured skin fibroblasts derived from Nubian goats deficient in lysosomal β-mannosidase, which had previously been shown to accumulate storage oligosaccharides with the structures Manβ4GlcNAcβ4GlcNAc and Manβ4GlcNAc (in the ratio of 2.7:1) were evaluated for their ability to catabolize exogenous [3H]GlcN-labelled glycoproteins isolated from the secretions of cultured goat or human fibroblasts. Regardless of the source of exogenous labelled glycoprotein, affected goat fibroblasts took up the labelled glycoprotein from the culture medium and subsequently accumulated the same major labelled oligosaccharide, identified as Manβ4GlcNAcβ4GlcNAc; no such oligosaccharide accumulated in normal goat fibroblasts under the same conditions. Tunicamycin-treated affected fibroblasts also took up labelled exogenous glycoprotein and accumulated labelled storage trisaccharide, further suggesting the direct accumulation of storage trisaccharide from impaired glycoprotein-associated oligosaccharide catabolism. Treatment of metabolically labelled affected fibroblasts with leupeptin, an inhibitor of lysosomal cathepsins, resulted in the 2- to 6-fold inhibition of trisaccharide accumulation, while having little effect on the uptake of [3H]GlcN or the accumulation of labelled disaccharide. The results are most consistent with the presence of two endoglycosidases, an endo-β-N-acetylglucosaminidase and an endo-aspartylglucosaminidase, in goat fibroblasts. These two activities, rather than heterogeneous core oligosaccharide structures, are responsible for the ultimate accumulation of storage oligosaccharides with one and two GlcNAc residues at their reducing terminus." @default.
• W2015453107 created "2016-06-24" @default.
• W2015453107 creator A5033533342 @default.
• W2015453107 creator A5054110947 @default.
• W2015453107 date "1987-04-01" @default.
• W2015453107 modified "2023-09-25" @default.
• W2015453107 title "Evidence for two catabolic endoglycosidase activities in β-mannosidase-deficient goat fibroblasts" @default.
• W2015453107 cites W1160821720 @default.
• W2015453107 cites W123314471 @default.
• W2015453107 cites W1492878067 @default.
• W2015453107 cites W1500055799 @default.
• W2015453107 cites W1563343269 @default.
• W2015453107 cites W1565040791 @default.
• W2015453107 cites W1572734449 @default.
• W2015453107 cites W1595236450 @default.
• W2015453107 cites W1603142270 @default.
• W2015453107 cites W1630477067 @default.
• W2015453107 cites W1672168449 @default.
• W2015453107 cites W1775749144 @default.
• W2015453107 cites W1982108493 @default.
• W2015453107 cites W1999797306 @default.
• W2015453107 cites W2004060617 @default.
• W2015453107 cites W2011790964 @default.
• W2015453107 cites W2025174325 @default.
• W2015453107 cites W2048228879 @default.
• W2015453107 cites W2055745237 @default.
• W2015453107 cites W2069208302 @default.
• W2015453107 cites W2085689371 @default.
• W2015453107 cites W2098719189 @default.
• W2015453107 cites W2120260066 @default.
• W2015453107 cites W2138032992 @default.
• W2015453107 cites W2196616199 @default.
• W2015453107 cites W2254662574 @default.
• W2015453107 cites W2255916609 @default.
• W2015453107 cites W2261042774 @default.
• W2015453107 cites W2261815824 @default.
• W2015453107 cites W2324079866 @default.
• W2015453107 cites W2337758138 @default.
• W2015453107 doi "https://doi.org/10.1016/0167-4889(87)90080-2" @default.
• W2015453107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2950933" @default.
• W2015453107 hasPublicationYear "1987" @default.
• W2015453107 type Work @default.
• W2015453107 sameAs 2015453107 @default.
• W2015453107 citedByCount "6" @default.
• W2015453107 crossrefType "journal-article" @default.
• W2015453107 hasAuthorship W2015453107A5033533342 @default.
• W2015453107 hasAuthorship W2015453107A5054110947 @default.
• W2015453107 hasConcept C108625454 @default.
• W2015453107 hasConcept C139447449 @default.
• W2015453107 hasConcept C153911025 @default.
• W2015453107 hasConcept C158617107 @default.
• W2015453107 hasConcept C181199279 @default.
• W2015453107 hasConcept C185592680 @default.
• W2015453107 hasConcept C196032511 @default.
• W2015453107 hasConcept C202751555 @default.
• W2015453107 hasConcept C2777174400 @default.
• W2015453107 hasConcept C2777575526 @default.
• W2015453107 hasConcept C2777726330 @default.
• W2015453107 hasConcept C2778312041 @default.
• W2015453107 hasConcept C2780381497 @default.
• W2015453107 hasConcept C2780654058 @default.
• W2015453107 hasConcept C2781060939 @default.
• W2015453107 hasConcept C55493867 @default.
• W2015453107 hasConcept C62231903 @default.
• W2015453107 hasConcept C86803240 @default.
• W2015453107 hasConcept C96942376 @default.
• W2015453107 hasConceptScore W2015453107C108625454 @default.
• W2015453107 hasConceptScore W2015453107C139447449 @default.
• W2015453107 hasConceptScore W2015453107C153911025 @default.
• W2015453107 hasConceptScore W2015453107C158617107 @default.
• W2015453107 hasConceptScore W2015453107C181199279 @default.
• W2015453107 hasConceptScore W2015453107C185592680 @default.
• W2015453107 hasConceptScore W2015453107C196032511 @default.
• W2015453107 hasConceptScore W2015453107C202751555 @default.
• W2015453107 hasConceptScore W2015453107C2777174400 @default.
• W2015453107 hasConceptScore W2015453107C2777575526 @default.
• W2015453107 hasConceptScore W2015453107C2777726330 @default.
• W2015453107 hasConceptScore W2015453107C2778312041 @default.
• W2015453107 hasConceptScore W2015453107C2780381497 @default.
• W2015453107 hasConceptScore W2015453107C2780654058 @default.
• W2015453107 hasConceptScore W2015453107C2781060939 @default.
• W2015453107 hasConceptScore W2015453107C55493867 @default.
• W2015453107 hasConceptScore W2015453107C62231903 @default.
• W2015453107 hasConceptScore W2015453107C86803240 @default.
• W2015453107 hasConceptScore W2015453107C96942376 @default.
• W2015453107 hasIssue "1" @default.
• W2015453107 hasLocation W20154531071 @default.
• W2015453107 hasLocation W20154531072 @default.
• W2015453107 hasOpenAccess W2015453107 @default.
• W2015453107 hasPrimaryLocation W20154531071 @default.
• W2015453107 hasRelatedWork W1534909388 @default.
• W2015453107 hasRelatedWork W1541408445 @default.
• W2015453107 hasRelatedWork W1835582018 @default.
• W2015453107 hasRelatedWork W1981905369 @default.
• W2015453107 hasRelatedWork W1992245891 @default.
• W2015453107 hasRelatedWork W2015453107 @default.
• W2015453107 hasRelatedWork W2057852190 @default.
• W2015453107 hasRelatedWork W2072511979 @default.

• next