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- W2015453432 abstract "The molecular defects recently identified in the rare monogenic autoimmune diseases (AIDs) have pinpointed critical steps in the pathways that contribute to the development of normal immune responses and self-tolerance. Recent studies of autoimmune polyendocrinopathy syndrome type 1, autoimmune lymphoproliferative syndrome, immunodysregulation, polyendocrinopathy and enteropathy, X-linked, IL-2 receptor alpha-chain deficiency, and, in particular, their corresponding mouse models, have revealed the details of the molecular mechanisms of normal immune tolerance, and exposed how defects in these mechanisms result in human autoimmunity. In addition to a deeper understanding of the immune system, detailed molecular characterization of monogenic AIDs will help us to understand the mechanisms behind common polygenic AIDs and, furthermore, to develop novel therapies and intervention strategies to treat them." @default.
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- W2015453432 date "2005-12-01" @default.
- W2015453432 modified "2023-09-25" @default.
- W2015453432 title "Monogenic autoimmune diseases — lessons of self-tolerance" @default.
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- W2015453432 doi "https://doi.org/10.1016/j.coi.2005.09.006" @default.
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