Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015456438> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2015456438 endingPage "58" @default.
- W2015456438 startingPage "51" @default.
- W2015456438 abstract "In potassium-depolarized guinea-pig left atria treated with isoproterenol, calcium entry blocking activities of adenosine and its potentiating compounds, dipyridamole, lidoflazine and dilazep were studied and compared to verapamil and diltiazem. pA2 values for various drugs were calculated using concentration-response curves for calcium (parallel shift to the right). The order of potency for the calcium entry blocking effect was: verapamil > diltiazem > adenosine > lidoflazine = dilazep > dipyridamole. Adenosine caused negative inotropic effects in depolarized left atria. The negative inotropic effect of adenosine was very quick in onset and was potentiated by erythro-6-amino-9(2-hydroxy-3-nonyl)-purine hydrochloride (EHNA), an adenosine deaminase inhibitor, suggesting that adenosine was being degraded. The effect of adenosine was quickly abolished by adenosine deaminase (ADA) and antagonized by 8-phenyltheophylline (8-PT), suggesting that the action of adenosine was most likely through the surface membrane receptor sites. The negative inotropic effects of dilazep and dipyridamole were only partially reversed by ADA and 8-PT, while that of lidoflazine was not affected by these agents. These findings suggest that the mechanism(s) of negative intotropic effect of lidoflazine was different from that of dilazep and dipyridamole. These data suggest that the negative intropic effect of dilazep is most likely due to a direct calcium entry blocking effect and in part due to its adenosine potentiating effect. However, the calcium entry blocking effect of lidoflazine is independent of adenosine." @default.
- W2015456438 created "2016-06-24" @default.
- W2015456438 creator A5000385176 @default.
- W2015456438 creator A5012703615 @default.
- W2015456438 creator A5024537221 @default.
- W2015456438 date "1986-03-01" @default.
- W2015456438 modified "2023-09-26" @default.
- W2015456438 title "Calcium entry blocking activity of dilazep and other adenosine potentiating compounds in guinea-pig atria" @default.
- W2015456438 cites W1970392387 @default.
- W2015456438 cites W1980848908 @default.
- W2015456438 cites W1987287683 @default.
- W2015456438 cites W2024103005 @default.
- W2015456438 cites W2027073527 @default.
- W2015456438 cites W2034150239 @default.
- W2015456438 cites W2039601108 @default.
- W2015456438 cites W2042251850 @default.
- W2015456438 cites W2044976104 @default.
- W2015456438 cites W2057707182 @default.
- W2015456438 cites W2072469466 @default.
- W2015456438 cites W2078730301 @default.
- W2015456438 cites W2095691742 @default.
- W2015456438 cites W2100770709 @default.
- W2015456438 cites W2463781695 @default.
- W2015456438 doi "https://doi.org/10.1016/0014-2999(86)90157-3" @default.
- W2015456438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3956577" @default.
- W2015456438 hasPublicationYear "1986" @default.
- W2015456438 type Work @default.
- W2015456438 sameAs 2015456438 @default.
- W2015456438 citedByCount "16" @default.
- W2015456438 crossrefType "journal-article" @default.
- W2015456438 hasAuthorship W2015456438A5000385176 @default.
- W2015456438 hasAuthorship W2015456438A5012703615 @default.
- W2015456438 hasAuthorship W2015456438A5024537221 @default.
- W2015456438 hasConcept C126322002 @default.
- W2015456438 hasConcept C134018914 @default.
- W2015456438 hasConcept C170493617 @default.
- W2015456438 hasConcept C178790620 @default.
- W2015456438 hasConcept C182683403 @default.
- W2015456438 hasConcept C185592680 @default.
- W2015456438 hasConcept C2776741139 @default.
- W2015456438 hasConcept C2776770532 @default.
- W2015456438 hasConcept C2776890861 @default.
- W2015456438 hasConcept C2776991684 @default.
- W2015456438 hasConcept C2777022698 @default.
- W2015456438 hasConcept C2778938600 @default.
- W2015456438 hasConcept C34628245 @default.
- W2015456438 hasConcept C519063684 @default.
- W2015456438 hasConcept C55493867 @default.
- W2015456438 hasConcept C67907053 @default.
- W2015456438 hasConcept C71924100 @default.
- W2015456438 hasConcept C98274493 @default.
- W2015456438 hasConceptScore W2015456438C126322002 @default.
- W2015456438 hasConceptScore W2015456438C134018914 @default.
- W2015456438 hasConceptScore W2015456438C170493617 @default.
- W2015456438 hasConceptScore W2015456438C178790620 @default.
- W2015456438 hasConceptScore W2015456438C182683403 @default.
- W2015456438 hasConceptScore W2015456438C185592680 @default.
- W2015456438 hasConceptScore W2015456438C2776741139 @default.
- W2015456438 hasConceptScore W2015456438C2776770532 @default.
- W2015456438 hasConceptScore W2015456438C2776890861 @default.
- W2015456438 hasConceptScore W2015456438C2776991684 @default.
- W2015456438 hasConceptScore W2015456438C2777022698 @default.
- W2015456438 hasConceptScore W2015456438C2778938600 @default.
- W2015456438 hasConceptScore W2015456438C34628245 @default.
- W2015456438 hasConceptScore W2015456438C519063684 @default.
- W2015456438 hasConceptScore W2015456438C55493867 @default.
- W2015456438 hasConceptScore W2015456438C67907053 @default.
- W2015456438 hasConceptScore W2015456438C71924100 @default.
- W2015456438 hasConceptScore W2015456438C98274493 @default.
- W2015456438 hasIssue "1" @default.
- W2015456438 hasLocation W20154564381 @default.
- W2015456438 hasLocation W20154564382 @default.
- W2015456438 hasOpenAccess W2015456438 @default.
- W2015456438 hasPrimaryLocation W20154564381 @default.
- W2015456438 hasRelatedWork W1983247666 @default.
- W2015456438 hasRelatedWork W2001596142 @default.
- W2015456438 hasRelatedWork W2015456438 @default.
- W2015456438 hasRelatedWork W2019407832 @default.
- W2015456438 hasRelatedWork W2023731942 @default.
- W2015456438 hasRelatedWork W2050535310 @default.
- W2015456438 hasRelatedWork W2090999896 @default.
- W2015456438 hasRelatedWork W2281285345 @default.
- W2015456438 hasRelatedWork W2291590107 @default.
- W2015456438 hasRelatedWork W2398262967 @default.
- W2015456438 hasVolume "122" @default.
- W2015456438 isParatext "false" @default.
- W2015456438 isRetracted "false" @default.
- W2015456438 magId "2015456438" @default.
- W2015456438 workType "article" @default.