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- W2015462089 abstract "Diamide sensitizes hypoxic mammalian cells to x radiation in a complex manner. It sensitizes CHO cells more effectively than V79-S171 cells and is far more efficient at 0$sup 0$C than at 18$sup 0$C in the presence of glucose. In the cold, diamide is more efficient than either nifuroxime or metronidazole (Flagyl), but this advantage is lost at 18$sup 0$C. Low concentrations of diamide (40 to 100 $mu$M, depending on cell line) decrease the extrapolation number to or close to 1 while affecting the D$sub 0$ only slightly, but higher concentrations decrease the D$sub 0$ to the euoxic level. The single-dose survival of V79 cells irradiated in the presence of increasing diamide concentrations follows a biphasic curve, with a break in the region of 200 to 300 $mu$M. Since diamide is not inactivated by x radiation and since there is no evidence of differential sensitization of cells in M, G$sub 1$, late S, or plateau-phase G$sub 1$/G$sub 0$, we interpret these data to mean that diamide acts by at least two mechanisms, one operating mainly at low concentrations to reduce the shoulder and the other predominating at high concentrations to decrease the D$sub 0$. (auth)" @default.
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- W2015462089 date "1975-11-01" @default.
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- W2015462089 title "Radiosensitization of Hypoxic Mammalian Cells by Diamide: I. Effects of Experimental Conditions on Survival" @default.
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- W2015462089 doi "https://doi.org/10.2307/3574264" @default.
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