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• W2015468184 abstract "Strenuous endurance exercise can adversely affect the mechanical integrity of immature bone, but it is unclear whether a more moderate exercise regimen would have a positive effect. Thus, to investigate the response of immature trabecular bone to moderate exercise, we randomly assigned female Sprague-Dawley rats (8 weeks old) to either a basal-control, exercise, or age-matched control group. The basal-control rats were killed at 8 weeks of age, while the other two groups were killed at 18 weeks of age. Between 8 and 18 weeks, one group remained sedentary, while another group was trained progressively on a motor-driven treadmill at a moderate level of intensity. Rat femoral necks (FN) were tested in cantilever bending to failure, and the sixth lumbar vertebral bodies (L6) were compressed to 50% of their initial height. Both tissues were analyzed for calcium, hydroxyproline, and collagen-crosslinking concentrations, and for changes in geometry. The adrenal mass per unit body mass was significantly greater in the exercised group, compared to the age-matched controls. L6 calcium content, compressional stress, and elastic modulus were significantly less in the exercise group as compared to the age-matched control group. Nonreducible collagen crosslinks (hydroxylysylpyridinoline [HP] and lysylpyridinoline [LP]) were significantly greater in the older exercise and age-matched control L6 and FN. In the weightbearing FN--but not L6--the LP concentration of the exercise group was significantly greater than the age-matched controls.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
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• W2015468184 date "1993-07-01" @default.
• W2015468184 modified "2023-09-27" @default.
• W2015468184 title "Adaptations of immature trabecular bone to moderate exercise: Geometrical, biochemical, and biomechanical correlates" @default.
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• W2015468184 doi "https://doi.org/10.1016/8756-3282(93)90087-q" @default.
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