Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015469836> ?p ?o ?g. }
- W2015469836 endingPage "2285" @default.
- W2015469836 startingPage "2275" @default.
- W2015469836 abstract "We provide evidence supporting that protein-protein and protein-ligand docking poses are functions of protein shape and intrinsic dynamics. Over sets of 68 protein-protein complexes and 240 nonhomologous enzymes, we recognize common predispositions for binding sites to have minimal vibrations and angular momenta, while two interacting proteins orient so as to maximize the angle between their rotation/bending axes (>65°). The findings are then used to define quantitative criteria to filter out docking decoys less likely to be the near-native poses; hence, the chances to find near-native hits can be doubled. With the novel approach to partition a protein into domains of robust but disparate intrinsic dynamics, 90% of catalytic residues in enzymes can be found within the first 50% of the residues closest to the interface of these dynamics domains. The results suggest an anisotropic rather than isotropic distribution of catalytic residues near the mass centers of enzymes." @default.
- W2015469836 created "2016-06-24" @default.
- W2015469836 creator A5003311977 @default.
- W2015469836 creator A5008880759 @default.
- W2015469836 creator A5052772145 @default.
- W2015469836 creator A5084253888 @default.
- W2015469836 date "2014-08-14" @default.
- W2015469836 modified "2023-09-29" @default.
- W2015469836 title "Molecular Binding Sites Are Located Near the Interface of Intrinsic Dynamics Domains (IDDs)" @default.
- W2015469836 cites W1760680901 @default.
- W2015469836 cites W1964640688 @default.
- W2015469836 cites W1966041739 @default.
- W2015469836 cites W1971528338 @default.
- W2015469836 cites W1980961615 @default.
- W2015469836 cites W1998643862 @default.
- W2015469836 cites W2000383223 @default.
- W2015469836 cites W2000813652 @default.
- W2015469836 cites W2001619934 @default.
- W2015469836 cites W2011691446 @default.
- W2015469836 cites W2014744153 @default.
- W2015469836 cites W2035503835 @default.
- W2015469836 cites W2040411019 @default.
- W2015469836 cites W2043383780 @default.
- W2015469836 cites W2055001560 @default.
- W2015469836 cites W2060619005 @default.
- W2015469836 cites W2071204652 @default.
- W2015469836 cites W2073984290 @default.
- W2015469836 cites W2085227451 @default.
- W2015469836 cites W2093290514 @default.
- W2015469836 cites W2098933757 @default.
- W2015469836 cites W2108700551 @default.
- W2015469836 cites W2112033855 @default.
- W2015469836 cites W2113994268 @default.
- W2015469836 cites W2133712572 @default.
- W2015469836 cites W2133842820 @default.
- W2015469836 cites W2139026081 @default.
- W2015469836 cites W2141504884 @default.
- W2015469836 cites W2142595184 @default.
- W2015469836 cites W2146332813 @default.
- W2015469836 cites W2151424650 @default.
- W2015469836 cites W2153304705 @default.
- W2015469836 cites W2153731681 @default.
- W2015469836 cites W2157576293 @default.
- W2015469836 cites W2160975112 @default.
- W2015469836 cites W2162682281 @default.
- W2015469836 cites W2166323701 @default.
- W2015469836 cites W2290195878 @default.
- W2015469836 cites W2315317366 @default.
- W2015469836 cites W2915344963 @default.
- W2015469836 cites W4251542659 @default.
- W2015469836 cites W4252827053 @default.
- W2015469836 cites W4255375128 @default.
- W2015469836 doi "https://doi.org/10.1021/ci500261z" @default.
- W2015469836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25089914" @default.
- W2015469836 hasPublicationYear "2014" @default.
- W2015469836 type Work @default.
- W2015469836 sameAs 2015469836 @default.
- W2015469836 citedByCount "20" @default.
- W2015469836 countsByYear W20154698362015 @default.
- W2015469836 countsByYear W20154698362016 @default.
- W2015469836 countsByYear W20154698362017 @default.
- W2015469836 countsByYear W20154698362018 @default.
- W2015469836 countsByYear W20154698362019 @default.
- W2015469836 countsByYear W20154698362020 @default.
- W2015469836 countsByYear W20154698362021 @default.
- W2015469836 countsByYear W20154698362023 @default.
- W2015469836 crossrefType "journal-article" @default.
- W2015469836 hasAuthorship W2015469836A5003311977 @default.
- W2015469836 hasAuthorship W2015469836A5008880759 @default.
- W2015469836 hasAuthorship W2015469836A5052772145 @default.
- W2015469836 hasAuthorship W2015469836A5084253888 @default.
- W2015469836 hasConcept C121332964 @default.
- W2015469836 hasConcept C12554922 @default.
- W2015469836 hasConcept C147597530 @default.
- W2015469836 hasConcept C159110408 @default.
- W2015469836 hasConcept C159467904 @default.
- W2015469836 hasConcept C184050105 @default.
- W2015469836 hasConcept C185592680 @default.
- W2015469836 hasConcept C186060115 @default.
- W2015469836 hasConcept C2775981520 @default.
- W2015469836 hasConcept C41685203 @default.
- W2015469836 hasConcept C47701112 @default.
- W2015469836 hasConcept C55493867 @default.
- W2015469836 hasConcept C59593255 @default.
- W2015469836 hasConcept C62520636 @default.
- W2015469836 hasConcept C71924100 @default.
- W2015469836 hasConcept C86803240 @default.
- W2015469836 hasConceptScore W2015469836C121332964 @default.
- W2015469836 hasConceptScore W2015469836C12554922 @default.
- W2015469836 hasConceptScore W2015469836C147597530 @default.
- W2015469836 hasConceptScore W2015469836C159110408 @default.
- W2015469836 hasConceptScore W2015469836C159467904 @default.
- W2015469836 hasConceptScore W2015469836C184050105 @default.
- W2015469836 hasConceptScore W2015469836C185592680 @default.
- W2015469836 hasConceptScore W2015469836C186060115 @default.
- W2015469836 hasConceptScore W2015469836C2775981520 @default.
- W2015469836 hasConceptScore W2015469836C41685203 @default.
- W2015469836 hasConceptScore W2015469836C47701112 @default.