Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015472023> ?p ?o ?g. }
- W2015472023 endingPage "784" @default.
- W2015472023 startingPage "777" @default.
- W2015472023 abstract "The cellular mechanisms that directly regulate the inflammatory response after Toll-like receptor (TLR) stimulation are unresolved at present. Here we report that glycogen synthase kinase 3 (GSK3) differentially regulates TLR-mediated production of pro- and anti-inflammatory cytokines. Stimulation of monocytes or peripheral blood mononuclear cells with TLR2, TLR4, TLR5 or TLR9 agonists induced substantial increases in interleukin 10 production while suppressing the release of proinflammatory cytokines after GSK3 inhibition. GSK3 regulated the inflammatory response by differentially affecting the nuclear amounts of transcription factors NF-kappaB subunit p65 and CREB interacting with the coactivator CBP. Administration of a GSK3 inhibitor potently suppressed the proinflammatory response in mice receiving lipopolysaccharide and mediated protection from endotoxin shock. These findings demonstrate a regulatory function for GSK3 in modulating the inflammatory response." @default.
- W2015472023 created "2016-06-24" @default.
- W2015472023 creator A5034719023 @default.
- W2015472023 creator A5037199856 @default.
- W2015472023 creator A5053406872 @default.
- W2015472023 creator A5061674181 @default.
- W2015472023 date "2005-07-10" @default.
- W2015472023 modified "2023-10-17" @default.
- W2015472023 title "Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3" @default.
- W2015472023 cites W10482017 @default.
- W2015472023 cites W1482682744 @default.
- W2015472023 cites W1483162601 @default.
- W2015472023 cites W1485363052 @default.
- W2015472023 cites W1568165627 @default.
- W2015472023 cites W1568605582 @default.
- W2015472023 cites W1593569420 @default.
- W2015472023 cites W1834719122 @default.
- W2015472023 cites W1872118948 @default.
- W2015472023 cites W1897355343 @default.
- W2015472023 cites W1908445283 @default.
- W2015472023 cites W1964378600 @default.
- W2015472023 cites W1965471441 @default.
- W2015472023 cites W1972343960 @default.
- W2015472023 cites W1973837499 @default.
- W2015472023 cites W1979993283 @default.
- W2015472023 cites W1980547319 @default.
- W2015472023 cites W1983055247 @default.
- W2015472023 cites W1985118687 @default.
- W2015472023 cites W1999171863 @default.
- W2015472023 cites W2010817360 @default.
- W2015472023 cites W2012868552 @default.
- W2015472023 cites W2035868461 @default.
- W2015472023 cites W2042295490 @default.
- W2015472023 cites W2055882175 @default.
- W2015472023 cites W2058138221 @default.
- W2015472023 cites W2070732456 @default.
- W2015472023 cites W2071213784 @default.
- W2015472023 cites W2079092923 @default.
- W2015472023 cites W2083308747 @default.
- W2015472023 cites W2088220499 @default.
- W2015472023 cites W2092250990 @default.
- W2015472023 cites W2094068658 @default.
- W2015472023 cites W2106877484 @default.
- W2015472023 cites W2112977087 @default.
- W2015472023 cites W2115893060 @default.
- W2015472023 cites W2123795063 @default.
- W2015472023 cites W2127136381 @default.
- W2015472023 cites W2127532387 @default.
- W2015472023 cites W2133627256 @default.
- W2015472023 cites W2153188511 @default.
- W2015472023 cites W2156445477 @default.
- W2015472023 cites W2158255311 @default.
- W2015472023 cites W2167085933 @default.
- W2015472023 cites W2168007983 @default.
- W2015472023 cites W2170966854 @default.
- W2015472023 cites W2178382797 @default.
- W2015472023 cites W2620241325 @default.
- W2015472023 cites W3023923910 @default.
- W2015472023 doi "https://doi.org/10.1038/ni1221" @default.
- W2015472023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1933525" @default.
- W2015472023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16007092" @default.
- W2015472023 hasPublicationYear "2005" @default.
- W2015472023 type Work @default.
- W2015472023 sameAs 2015472023 @default.
- W2015472023 citedByCount "964" @default.
- W2015472023 countsByYear W20154720232012 @default.
- W2015472023 countsByYear W20154720232013 @default.
- W2015472023 countsByYear W20154720232014 @default.
- W2015472023 countsByYear W20154720232015 @default.
- W2015472023 countsByYear W20154720232016 @default.
- W2015472023 countsByYear W20154720232017 @default.
- W2015472023 countsByYear W20154720232018 @default.
- W2015472023 countsByYear W20154720232019 @default.
- W2015472023 countsByYear W20154720232020 @default.
- W2015472023 countsByYear W20154720232021 @default.
- W2015472023 countsByYear W20154720232022 @default.
- W2015472023 countsByYear W20154720232023 @default.
- W2015472023 crossrefType "journal-article" @default.
- W2015472023 hasAuthorship W2015472023A5034719023 @default.
- W2015472023 hasAuthorship W2015472023A5037199856 @default.
- W2015472023 hasAuthorship W2015472023A5053406872 @default.
- W2015472023 hasAuthorship W2015472023A5061674181 @default.
- W2015472023 hasBestOaLocation W20154720232 @default.
- W2015472023 hasConcept C104317684 @default.
- W2015472023 hasConcept C104629339 @default.
- W2015472023 hasConcept C11960822 @default.
- W2015472023 hasConcept C136449434 @default.
- W2015472023 hasConcept C1629964 @default.
- W2015472023 hasConcept C164027704 @default.
- W2015472023 hasConcept C170493617 @default.
- W2015472023 hasConcept C182996813 @default.
- W2015472023 hasConcept C185592680 @default.
- W2015472023 hasConcept C192118531 @default.
- W2015472023 hasConcept C203014093 @default.
- W2015472023 hasConcept C2776070231 @default.
- W2015472023 hasConcept C2776603820 @default.
- W2015472023 hasConcept C2776709828 @default.
- W2015472023 hasConcept C2776914184 @default.