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• W2015472486 abstract "Objective: The aim of this study was to apply a prototype system for performing real-time freehand ultrasound (US) strain imaging of breast masses, and make an initial evaluation of the strain data obtained. Methods: US strain images were obtained using a prototype algorithm on a commercial Siemens Elegra US system. Radio-frequency (RF) data were stored during strain imaging of 16 lesions (9 malignant, 7 benign). Stored RF sequences were selected based on real-time review of strain images during acquisition. Two regions of interest (ROIs) were defined for each strain image sequence, one over the lesion, and one over normal breast tissue. Strain images exhibiting appreciable noise were excluded from the analysis. Mean ROI pixel values were computed, resulting in a sequence of paired lesion and normal tissue strain measurements, which were plotted against one another, and fitted to a line. The slope of the line represents a measure of the relative lesion strain compared to normal tissue and, assuming uniform stress and linear mechanical properties, is a measure of the relative tissue stiffness. Results: The fits included ≥ 50 frames in 14/16 cases. The correlation coefficients (r) were > 0.85 in 15/16 cases, and r > 0.90 in 9/16 cases. The y-intercepts were all within 2 standard deviations (SDs) of zero. All slopes were < 1, indicating the lesions were stiffer than normal tissue. Slope SDs ranged from 2–12%, and in 14 cases slope SDs were ≤ 10%. Slopes for malignant lesions ranged from 0.10–0.87, while benign lesion slopes ranged from 0.18–0.41. The overlap of the relative strains for benign and malignant lesions may be due to a range of stiffness of normal breast tissue, which has been previously reported. Methods to overcome normal tissue variability would include measuring applied stress, or measuring the strain of a known standard. Conclusions: Our preliminary study suggests that strain data of good quality may be obtained using the prototype freehand US strain imaging system. Differentiation of benign from malignant lesions may require measurements of applied stress or of a strain standard, and refinement of the mechanical model. Future work will investigate these topics, and establish the repeatability of the strain measurements." @default.
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• W2015472486 date "2003-05-01" @default.
• W2015472486 modified "2023-09-27" @default.
• W2015472486 title "Ultrasound strain image data obtained in breast masses: preliminary quantitative analysis" @default.
• W2015472486 doi "https://doi.org/10.1016/s0301-5629(03)00708-7" @default.
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