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• W2015472802 abstract "The interactions of five poly(oxyethylene)−poly(oxypropylene)−poly(oxyethylene) (PEO−PPO−PEO), Pluronic, copolymers and phosphatidylcholine liposomes of varying composition have been studied. Structural studies were performed by means of cryo-transmission electron microscopy (c-TEM) and reveal that inclusion of low amounts (∼2 mol %) of Pluronics gives rise to significant morphological changes of the liposome preparations. Pluronics with large poly(oxyethylene) (PEO) blocks, such as F127, F108, and F87, induce the formation of bilayer disks, whereas those with comparably short PEO blocks, P105 and P85, tend to to promote a reduction in the liposome size. Inclusion of cholesterol in the liposomal preparations reduces the incorporation of copolymers in the lipid bilayer and thus reduces, and in some cases even abolishes, the morphological changes observed in the absence of cholesterol. The effect of the copolymers on liposome permeability was also investigated. All investigated copolymers were found to incr..." @default.
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• W2015472802 date "1999-07-16" @default.
• W2015472802 modified "2023-10-14" @default.
• W2015472802 title "Effect of PEO−PPO−PEO Triblock Copolymers on Structure and Stability of Phosphatidylcholine Liposomes" @default.
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• W2015472802 doi "https://doi.org/10.1021/la990288+" @default.
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