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• W2015473009 abstract "Riboswitches are natural RNA sensors that affect post-transcriptional processes via their capacity to bind small molecules. To date, these mRNA structures have been shown to regulate the biosynthesis of essential metabolites, including vitamins and amino acids. Although bacterial riboswitches are widespread and characterized, only a single eukaryotic, thiamin-pyrophosphate-binding riboswitch has recently been discovered to direct gene expression by regulating mRNA splicing in fungi, green algae and land plants. It is unclear how widespread riboswitches are and what additional roles they have in eukaryotes. When engineered in plants, riboswitches can function autonomously to modulate gene expression. These discoveries not only trigger novel findings regarding RNA switches in plants, but also spur the exploitation of riboswitches for monitoring metabolite concentrations in planta. Riboswitches are natural RNA sensors that affect post-transcriptional processes via their capacity to bind small molecules. To date, these mRNA structures have been shown to regulate the biosynthesis of essential metabolites, including vitamins and amino acids. Although bacterial riboswitches are widespread and characterized, only a single eukaryotic, thiamin-pyrophosphate-binding riboswitch has recently been discovered to direct gene expression by regulating mRNA splicing in fungi, green algae and land plants. It is unclear how widespread riboswitches are and what additional roles they have in eukaryotes. When engineered in plants, riboswitches can function autonomously to modulate gene expression. These discoveries not only trigger novel findings regarding RNA switches in plants, but also spur the exploitation of riboswitches for monitoring metabolite concentrations in planta. oligonucleotide or peptide that has been selected from a large random pool for its capacity to bind a target molecule directly. sequences of mRNA molecules that directly bind to metabolites, the binding of which affects the adjacent gene expression. Typically, a riboswitch is made of a sensory domain, which binds the specific metabolite and an expression platform, which converts the information of the metabolite." @default.
• W2015473009 created "2016-06-24" @default.
• W2015473009 creator A5026316454 @default.
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• W2015473009 date "2008-10-01" @default.
• W2015473009 modified "2023-09-27" @default.
• W2015473009 title "Switching the light on plant riboswitches" @default.
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• W2015473009 doi "https://doi.org/10.1016/j.tplants.2008.07.004" @default.
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