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• W2015473709 endingPage "361" @default.
• W2015473709 startingPage "343" @default.
• W2015473709 abstract "The properties of the cholinesterase activity in homogenates of whole rat diaphragm and of innervated (+EP) and non-innervated (−EP) regions of the muscle have been investigated. Under standard assay conditions, over 90% of the cholinesterase activity of whole muscle homogenates was due to specific acetylcholinesterases. The specific activity of acetylcholinesterase was higher in +EP regions of muscle than in −EP regions. About 40% of the total activity was calculated to be specifically associated with the endplates. When a high speed supernatant fraction of muscles homogenized in 1 M NaCl, 0.5% Triton X-100 was subjected to velocity sedimentation in a sucrose gradient, and three species of acetylcholinesterase activity with sedimentation constants of 4 S, 10 S and 16 S were observed. All three forms were stable under the conditions of sedimentation and had buoyant densities of approximately 1.28. All three hydrolyzed β-methylacetylcholine at approximately 30% the rate that acetylcholine was hydrolyzed. The 10 S and 16 S forms were inhibited by concentrations of acetylcholine over 1.25 mM, but no substrate inhibition was observed with the 4 S enzyme. Velocity sedimentation of extracts from +EP and −EP regions of muscle demonstrated that the 4 S and 10 S forms of the enzyme were distributed throughout the muscle while the 16 S form was found only in +EP regions. Extracts of the phrenic nerve contained only 4 S and 10 S forms. Thus, the 16 S form of acetylcholinesterase is specifically associated with endplate regions of muscle and may correspond to the endplate enzyme. Seven days after denervation of the diaphragm, both endplate-specific cholinesterase activity and the cholinesterase activity in −EP regions of muscle were decreased. Although the activity of all three forms of acetylcholinesterase were decreased in denervated muscle, the largest proportional decrease occurred in the activity of the 16 S form." @default.
• W2015473709 created "2016-06-24" @default.
• W2015473709 creator A5069247857 @default.
• W2015473709 date "1973-01-01" @default.
• W2015473709 modified "2023-10-15" @default.
• W2015473709 title "Multiple forms of acetylcholinesterase and their distribution in endplate and non-endplate regions of rat diaphragm muscle" @default.
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• W2015473709 doi "https://doi.org/10.1002/neu.480040404" @default.
• W2015473709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4724813" @default.
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