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- W2015474881 abstract "A novel adhesive coating was developed that allows even small quantities of immediate-release (IR) powders to be press-coated onto controlled-release (CR), coated dosage forms without damaging the CR coating. The process was exemplified using a pseudoephedrine osmotic tablet (asymmetric membrane technology, AMT) where a powder weighing less than 25% of the core was pressed onto the osmotic tablet providing a final combination tablet with low friability. The dosage form with the adhesive plus the press-coated powder showed comparable sustained drug release rates to the untreated dosage form after an initial 2-h lag. The adhesive layer consisted of an approximately 100- microm coating of Eudragit RL, polyethylene glycol (PEG) and triethyl citrate (TEC) at a ratio of 5:3:1.2. This coating provides a practical balance between handleability before press-coating and good adhesion." @default.
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- W2015474881 date "2003-05-01" @default.
- W2015474881 modified "2023-09-23" @default.
- W2015474881 title "Press-coating of immediate release powders onto coated controlled release tablets with adhesives" @default.
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- W2015474881 doi "https://doi.org/10.1016/s0168-3659(03)00132-9" @default.
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