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• W2015479119 abstract "Enriched null cell populations were obtained by fractionating blood mononuclear cells on discontinuous bovine serum albumin gradients. Null cells from 22 normals were compared to those from 14 patients with systemic lupus erythematosus who had various degrees of disease activity and to 8 patients with other autoimmune phenomena. Null cell layer lacked T cells (E rosette forming cells), cells with surface membrane immunoglobulin, cells capable of latex particles phagocytosis or cells capable of binding to IgG-coated human erythrocytes (EA rosette assay). Cells carrying receptors for complement were present. Cells of the null cell layer failed to respond in vitro to mitogens and allogeneic cells but were capable of Ig synthesis upon incubation with pokeweed mitogen. On transmission electron microscopy, null cells had large nucleus, narrow cytoplasm, and short surface processes. Null cells of SLE patients, when compared to normals, were increased in numbers (p < 0.01), and had the capacity to bind to native DNA (p < 0.01). Binding of cells to DNA could not be blocked by prior treatment of cells with anti-Ig antisera. There was a positive correlation between disease activity, null cell numbers, and DNA binding to serum or to the null cells. Defective maturation and/or differentiation of the null cells of SLE into mature cells with expansion of cell clones reactive to native DNA could be important in the pathogenesis of SLE. This could be due to the lack of maturation factors and/or rapid emigration of the precursor null cells from the stem cell compartment to the circulating pool." @default.
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• W2015479119 date "1976-01-01" @default.
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• W2015479119 title "Null cells in peripheral blood of normals and systemic lupus erythematosus" @default.
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• W2015479119 doi "https://doi.org/10.1016/0090-1229(76)90088-x" @default.
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