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• W2015481560 startingPage "293" @default.
• W2015481560 abstract "Involvement of the X chromosome in premature ovarian failure was demonstrated by the relatively frequent chromosomal rearrangements in patients, but the requirement of two X chromosomes for ovarian function was quite unexplained until recently. Review of the data on chromosomal rearrangements suggests that several genes along the X chromosomes contribute to ovarian function. In most instances, no single X chromosome gene has a causative role in premature ovarian failure, and the phenotype is likely to derive from the additive effect of X-linked and non-X-linked factors. Recent data on a small group of balanced X–autosome translocations showed that X-linked premature ovarian failure might also be caused by a different mechanism, namely position effect of the X chromosome on non-X-linked genes, and suggest a peculiar organization of the X chromosome during oogenesis." @default.
• W2015481560 created "2016-06-24" @default.
• W2015481560 creator A5048435323 @default.
• W2015481560 date "2006-06-01" @default.
• W2015481560 modified "2023-10-17" @default.
• W2015481560 title "X-linked premature ovarian failure: a complex disease" @default.
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• W2015481560 doi "https://doi.org/10.1016/j.gde.2006.04.005" @default.
• W2015481560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16650756" @default.
• W2015481560 hasPublicationYear "2006" @default.
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