Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015487966> ?p ?o ?g. }
- W2015487966 endingPage "17" @default.
- W2015487966 startingPage "1" @default.
- W2015487966 abstract "Glutamine may have benefits during immaturity or critical illness in early life but its effects on outcome end hardpoints are controversial. Our aim was to review randomized studies on glutamine supplementation in pups, infants, and children examining whether glutamine affects outcome. Experimental work has proposed various mechanisms of glutamine action but none of the randomized studies in early life showed any effect on mortality and only a few showed some effect on inflammatory response, organ function, and a trend for infection control. Although apparently safe in animal models (pups), premature infants, and critically ill children, glutamine supplementation does not reduce mortality or late onset sepsis, and its routine use cannot be recommended in these sensitive populations. Large prospectively stratified trials are needed to better define the crucial interrelations of “glutamine-heat shock proteins-stress response” in critical illness and to identify the specific subgroups of premature neonates and critically ill infants or children who may have a greater need for glutamine and who may eventually benefit from its supplementation. The methodological problems noted in the reviewed randomized experimental and clinical trials should be seriously considered in any future well-designed large blinded randomized controlled trial involving glutamine supplementation in critical illness." @default.
- W2015487966 created "2016-06-24" @default.
- W2015487966 creator A5072668532 @default.
- W2015487966 creator A5086679939 @default.
- W2015487966 date "2012-01-01" @default.
- W2015487966 modified "2023-09-27" @default.
- W2015487966 title "Glutamine Randomized Studies in Early Life: The Unsolved Riddle of Experimental and Clinical Studies" @default.
- W2015487966 cites W1489131009 @default.
- W2015487966 cites W1521429354 @default.
- W2015487966 cites W1539486261 @default.
- W2015487966 cites W1868784768 @default.
- W2015487966 cites W1877864798 @default.
- W2015487966 cites W1913519730 @default.
- W2015487966 cites W1922075288 @default.
- W2015487966 cites W1930394836 @default.
- W2015487966 cites W1971974972 @default.
- W2015487966 cites W1973171540 @default.
- W2015487966 cites W1973744554 @default.
- W2015487966 cites W1977832275 @default.
- W2015487966 cites W1978269473 @default.
- W2015487966 cites W1978794637 @default.
- W2015487966 cites W1978814922 @default.
- W2015487966 cites W1979292938 @default.
- W2015487966 cites W1981158355 @default.
- W2015487966 cites W1981358050 @default.
- W2015487966 cites W1983161480 @default.
- W2015487966 cites W1985132942 @default.
- W2015487966 cites W1987656606 @default.
- W2015487966 cites W1989849627 @default.
- W2015487966 cites W1992290437 @default.
- W2015487966 cites W1996590291 @default.
- W2015487966 cites W2002894974 @default.
- W2015487966 cites W2005467173 @default.
- W2015487966 cites W2009112498 @default.
- W2015487966 cites W2010024335 @default.
- W2015487966 cites W2014034051 @default.
- W2015487966 cites W2016308346 @default.
- W2015487966 cites W2018649485 @default.
- W2015487966 cites W2028812539 @default.
- W2015487966 cites W2029372981 @default.
- W2015487966 cites W2030292192 @default.
- W2015487966 cites W2031989381 @default.
- W2015487966 cites W2032122752 @default.
- W2015487966 cites W2038168279 @default.
- W2015487966 cites W2038459645 @default.
- W2015487966 cites W2039952309 @default.
- W2015487966 cites W2040568164 @default.
- W2015487966 cites W2041488900 @default.
- W2015487966 cites W2044672038 @default.
- W2015487966 cites W2046090274 @default.
- W2015487966 cites W2048238764 @default.
- W2015487966 cites W2048527381 @default.
- W2015487966 cites W2049927822 @default.
- W2015487966 cites W2053502474 @default.
- W2015487966 cites W2053940626 @default.
- W2015487966 cites W2054337155 @default.
- W2015487966 cites W2054382909 @default.
- W2015487966 cites W2054386531 @default.
- W2015487966 cites W2054953787 @default.
- W2015487966 cites W2058595614 @default.
- W2015487966 cites W2059126613 @default.
- W2015487966 cites W2060139051 @default.
- W2015487966 cites W2060832516 @default.
- W2015487966 cites W2065502556 @default.
- W2015487966 cites W2071137111 @default.
- W2015487966 cites W2076065146 @default.
- W2015487966 cites W2076280550 @default.
- W2015487966 cites W2076479783 @default.
- W2015487966 cites W2080927604 @default.
- W2015487966 cites W2085380653 @default.
- W2015487966 cites W2085971070 @default.
- W2015487966 cites W2087668297 @default.
- W2015487966 cites W2095295709 @default.
- W2015487966 cites W2096570619 @default.
- W2015487966 cites W2098294394 @default.
- W2015487966 cites W2100339936 @default.
- W2015487966 cites W2100489183 @default.
- W2015487966 cites W2108438598 @default.
- W2015487966 cites W2109336416 @default.
- W2015487966 cites W2109383171 @default.
- W2015487966 cites W2110387026 @default.
- W2015487966 cites W2110795699 @default.
- W2015487966 cites W2111380211 @default.
- W2015487966 cites W2112855348 @default.
- W2015487966 cites W2117333896 @default.
- W2015487966 cites W2117615391 @default.
- W2015487966 cites W2119647378 @default.
- W2015487966 cites W2120866264 @default.
- W2015487966 cites W2121184716 @default.
- W2015487966 cites W2123533526 @default.
- W2015487966 cites W2129923513 @default.
- W2015487966 cites W2133071442 @default.
- W2015487966 cites W2133182832 @default.
- W2015487966 cites W2135676799 @default.
- W2015487966 cites W2137842935 @default.
- W2015487966 cites W2139190393 @default.
- W2015487966 cites W2139896168 @default.
- W2015487966 cites W2141807632 @default.