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- W2015489315 abstract "Our previous study elucidated that JWA protein was a newly identified microtubule-associated protein (MAP), which combined to and co-localized with p-tubulin. In the present study, we designed a series of experiments to explore if any interactions between JWA protein and α-tubulin existed and how JWA protein would functionally link to α-tubulin, especially in cell mitosis. Results of co-immunoprecipitation, gene transfection and immunofluores-cence microscopy from PC12 and HEK293 cells provided strong evidence for a linkage between JWA protein and a-tubulin. Our data showed that JWA protein bound to a-tubulin stably no matter whether a-tubulin was polymerized or not. In addition, by using antisense oligonucleotides, cell cycle blocking agents and hypothermia disposal techniques, we also found the interaction between JWA protein and a-tubulin. The further analysis using flow cytometry and confocal microscopy showed that both proteins co-existed in PC12 cells and were independent on the cell cycle. In conclusion, JWA protein is a newly identified microtubule-associated protein, binds to a-tubulin, and probably plays an important role in regulation of microtubular stability." @default.
- W2015489315 created "2016-06-24" @default.
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- W2015489315 date "2004-01-01" @default.
- W2015489315 modified "2023-09-28" @default.
- W2015489315 title "JWA protein binds to a-tubulin in PC12 cells" @default.
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