FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015492017> ?p ?o ?g. }

• W2015492017 endingPage "898" @default.
• W2015492017 startingPage "893" @default.
• W2015492017 abstract "The nuclear factor (NF)-kappaB regulates inflammatory responses and plays important roles in the pathogenesis of acute respiratory distress syndrome (ARDS). Inhibitor kappaB-alpha (NFKBIA) inhibits NF-kappaB and controls its activities. The objective was to determine whether polymorphisms in NFKBIA gene would be associated with ARDS development.Prospective cohort of adults with clinical risk factors for ARDS.Hospital system.Patients were 1,210 critically ill Caucasian patients meeting study criteria for a defined risk factor for ARDS who were enrolled and prospectively followed for 60 days; 382 had ARDS, and 828 were controls.Genetic polymorphisms in the NFKBIA promoter (-881A/G, -826C/T, -297C/T) were determined using TaqMan techniques.The three polymorphisms were in Hardy-Weinberg equilibrium. No individual genotype was significantly associated with ARDS development. In contrast, haplotypes of NFKBIA were globally associated with ARDS development (p = .02, degree of freedom = 2). The frequency of haplotype GTC (-881G/-826T/-297C) was significantly higher among ARDS patients (7.4%) than that among controls (5.2%) (p = .03). Crude analysis showed that the haplotype GTC was significantly associated with higher risks of ARDS in the whole cohort compared with the common haplotype ACC (-881A/-826C/-297C) (odds ratio [OR], 1.47; 95% confidence interval [CI], 1.03-2.09; p = .03), especially among male subjects (OR, 1.90; 95% CI, 1.20-2.97; p < .01). After adjustment for covariates, the haplotype GTC remained significantly associated with increased risk of ARDS in the whole cohort (OR, 1.66; 95% CI, 1.09-2.53; p = .02), particularly among male patients (OR, 1.98; 95% CI, 1.16-3.40; p = .02) and among subjects with direct pulmonary injury (OR, 1.75; 95% CI, 1.04-2.95; p = .04).The haplotype GTC of NFKBIA gene is associated with higher risk of ARDS in Caucasians, particularly in male patients and in patients with direct lung injury." @default.
• W2015492017 created "2016-06-24" @default.
• W2015492017 creator A5020944879 @default.
• W2015492017 creator A5027406693 @default.
• W2015492017 creator A5035243580 @default.
• W2015492017 creator A5054149338 @default.
• W2015492017 creator A5056404361 @default.
• W2015492017 creator A5056487867 @default.
• W2015492017 creator A5081350789 @default.
• W2015492017 creator A5085322716 @default.
• W2015492017 date "2007-03-01" @default.
• W2015492017 modified "2023-10-05" @default.
• W2015492017 title "Inhibitor κB-α haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians*" @default.
• W2015492017 cites W1540037816 @default.
• W2015492017 cites W1837020737 @default.
• W2015492017 cites W1955941410 @default.
• W2015492017 cites W1971160226 @default.
• W2015492017 cites W1973170858 @default.
• W2015492017 cites W1988970377 @default.
• W2015492017 cites W1994778879 @default.
• W2015492017 cites W1995905907 @default.
• W2015492017 cites W2007402068 @default.
• W2015492017 cites W2014413418 @default.
• W2015492017 cites W2021363182 @default.
• W2015492017 cites W2023877008 @default.
• W2015492017 cites W2029361834 @default.
• W2015492017 cites W2033925475 @default.
• W2015492017 cites W2035826730 @default.
• W2015492017 cites W2039743266 @default.
• W2015492017 cites W2043910070 @default.
• W2015492017 cites W2063299162 @default.
• W2015492017 cites W2067489401 @default.
• W2015492017 cites W2070506007 @default.
• W2015492017 cites W2073417548 @default.
• W2015492017 cites W2075055228 @default.
• W2015492017 cites W2076637846 @default.
• W2015492017 cites W2078711199 @default.
• W2015492017 cites W2080766847 @default.
• W2015492017 cites W2084875349 @default.
• W2015492017 cites W2092629886 @default.
• W2015492017 cites W2093041845 @default.
• W2015492017 cites W2101791172 @default.
• W2015492017 cites W2107063140 @default.
• W2015492017 cites W2110002099 @default.
• W2015492017 cites W2121652706 @default.
• W2015492017 cites W2147265607 @default.
• W2015492017 cites W2159360736 @default.
• W2015492017 cites W2160670907 @default.
• W2015492017 cites W2217809488 @default.
• W2015492017 cites W4294658238 @default.
• W2015492017 cites W4361865037 @default.
• W2015492017 doi "https://doi.org/10.1097/01.ccm.0000256845.92640.38" @default.
• W2015492017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17235259" @default.
• W2015492017 hasPublicationYear "2007" @default.
• W2015492017 type Work @default.
• W2015492017 sameAs 2015492017 @default.
• W2015492017 citedByCount "41" @default.
• W2015492017 countsByYear W20154920172012 @default.
• W2015492017 countsByYear W20154920172013 @default.
• W2015492017 countsByYear W20154920172014 @default.
• W2015492017 countsByYear W20154920172015 @default.
• W2015492017 countsByYear W20154920172020 @default.
• W2015492017 crossrefType "journal-article" @default.
• W2015492017 hasAuthorship W2015492017A5020944879 @default.
• W2015492017 hasAuthorship W2015492017A5027406693 @default.
• W2015492017 hasAuthorship W2015492017A5035243580 @default.
• W2015492017 hasAuthorship W2015492017A5054149338 @default.
• W2015492017 hasAuthorship W2015492017A5056404361 @default.
• W2015492017 hasAuthorship W2015492017A5056487867 @default.
• W2015492017 hasAuthorship W2015492017A5081350789 @default.
• W2015492017 hasAuthorship W2015492017A5085322716 @default.
• W2015492017 hasConcept C104317684 @default.
• W2015492017 hasConcept C126322002 @default.
• W2015492017 hasConcept C135763542 @default.
• W2015492017 hasConcept C156957248 @default.
• W2015492017 hasConcept C188816634 @default.
• W2015492017 hasConcept C197754878 @default.
• W2015492017 hasConcept C201903717 @default.
• W2015492017 hasConcept C203014093 @default.
• W2015492017 hasConcept C2776348555 @default.
• W2015492017 hasConcept C2777714996 @default.
• W2015492017 hasConcept C44249647 @default.
• W2015492017 hasConcept C50440223 @default.
• W2015492017 hasConcept C54355233 @default.
• W2015492017 hasConcept C71924100 @default.
• W2015492017 hasConcept C72563966 @default.
• W2015492017 hasConcept C86803240 @default.
• W2015492017 hasConcept C90924648 @default.
• W2015492017 hasConceptScore W2015492017C104317684 @default.
• W2015492017 hasConceptScore W2015492017C126322002 @default.
• W2015492017 hasConceptScore W2015492017C135763542 @default.
• W2015492017 hasConceptScore W2015492017C156957248 @default.
• W2015492017 hasConceptScore W2015492017C188816634 @default.
• W2015492017 hasConceptScore W2015492017C197754878 @default.
• W2015492017 hasConceptScore W2015492017C201903717 @default.
• W2015492017 hasConceptScore W2015492017C203014093 @default.
• W2015492017 hasConceptScore W2015492017C2776348555 @default.
• W2015492017 hasConceptScore W2015492017C2777714996 @default.

• next