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• W2015495840 abstract "Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or niche influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population." @default.
• W2015495840 created "2016-06-24" @default.
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• W2015495840 date "2001-12-21" @default.
• W2015495840 modified "2023-10-17" @default.
• W2015495840 title "Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue" @default.
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• W2015495840 doi "https://doi.org/10.1126/science.1066707" @default.
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