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• W2015497227 abstract "Dog aortas and coronary arteries were perfused with the animal's own native serum for 8 h using pulsatile pressures. Lipid synthesis from [2-14C]acetate was compared with the corresponding lipid contents in three aortic layers and in coronary arteries. The influence of an atherogenic diet on the arterial lipids was studied in this system. In control animals, 14C-incorporation into the total lipids was highest and nearly identical in the coronary arteries and in the aortic intima including several layers of media (intima); incorporation into the lipids of the aortic adventitia and media was approximately one fifth, as compared to the intima. The percentage distribution of 14C label between the different lipids was identical in the intima and media. The intima contained the highest amount of unesterified fatty acids; the percentage 14C-incorporation was low and approximately the same in the aortic layers and in the coronary arteries (< 6%). The highest concentration of free sterols was found in the aortic media; they comprised approximately 90% of the total sterols in this tissue. The percentage radioactivity was low (< 5%) and within the same range in the aortic tissues and in coronary arteries. Sterolesters were mostly present in the coronary arteries paralleled by the highest percentage 14C-incorporation (3%); the low concentrations in the aortic layers were associated with low percentage redioactivities (< 1%). The diglyceride contents were low in both vessels; relatively high amounts and radioactivities (6%) of those lipids were found in the adventitia, as compared to the media (3%); 14C-activity was higher in the coronary arteries (10%). The triglyceride contents and the percentage 14C-activity were highest in the aortic adventitia (51%) and in the coronary arteries (25%); the concentrations were extremely low in the media and intima; radioactivity, however, was relatively high (11 and 14%). The smallest phosphatide amount was measured in the coronary arteries; 14C-incorporation was high in the intima and media (76%) and low in the adventitia (39%) and coronary arteries (53%). In animals fed on an atherogenic diet containing butter fat, sucrose, cholesterol and thiouracil as main constituents, a severe hyperlipemia was induced; glucose levels were unchanged. No morphological changes of the vessels and no alteration of the 14C-incorporation into the total lipids of aorta and coronary arteries were observed. However, the following significant changes of the lipid concentrations and the percentage 14C-distribution were demonstrated: The concentration of the unesterified fatty acids was reduced in the aortic intima; 14C-incorporation was only moderately diminished; the media responded reversely; the coronary arteries showed decreased radioactivities and slightly increased fatty acid contents. The amounts of free sterols were moderately elevated in the intima, and the corresponding percentage radioactivity was also increased. The sterol concentrations of the coronary arteries were unchanged, radioactivity, however, was diminished. Increased sterolester contents were seen in the intima and media; percentage radioactivity, however, was elevated in the adventitia and media. Augmented diglyceride concentrations were found in the media and in the coronary arteries; percentage 14C-activity was diminished in the adventitia and media. No relevant alterations were observed in the triglycerides and phosphatides of both vessels. In control animals, the [14C]acetate was mainly incorporated into the fatty acids of glycerides (98.5%) and phosphatides (94.6%); this difference was highly significant. The diet treated animals incorporated 100% radioactivity into the glyceride fatty acids, and 99% into the phosphatide fatty acids; this difference was also significant." @default.
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• W2015497227 title "Biosynthesis of lipids in perfused dog aorta and coronary artery I. Incorporation of [2-14C]acetate into the lipids of three aortic layers and of the coronary artery in normal and hyperlipemic dogs" @default.
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• W2015497227 doi "https://doi.org/10.1016/0022-2828(72)90093-4" @default.
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