FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015508032> ?p ?o ?g. }

• W2015508032 endingPage "2846" @default.
• W2015508032 startingPage "2837" @default.
• W2015508032 abstract "A highly sensitive and accurate method based on the precolumn derivatization of bile acids (BA) with a high ionization efficiency labeling reagent 1,2-benzo-3,4-dihydrocarbazole-9-ethyl-benzenesulfonate (BDEBS) coupled with LC/MS has been developed. After derivatization, BA molecules introduced a weak basic nitrogen atom into the molecular core structure that was readily ionized in commonly used acidic HPLC mobile phases. Derivatives were sufficiently stable to be efficiently analyzed by atmospheric pressure chemical ionization (APCI)-MS/MS in positive-ion mode. The MS/MS spectra of BA derivatives showed an intense protonated molecular ion at m/z [M + H]+. The collision-induced dissociation of the molecular ion produced fragment ions at [MH–H2O]+, [MH–2H2O]+, [MH–3H2O]+. The characteristic fragment ions were at m/z 320.8, 262.8, and 243.7 corresponding to a cleavage of N–CO, O–CO, and C–OCO, respectively, and bonds of derivatized molecules. The selected reaction monitoring, based on the m/z [M + H]+ → [MH–H2O]+, [MH–2H2O]+, [MH–3H2O]+, 320.8, 262.8, and 243.7 transitions, was highly specific for the BA derivatives. The LODs for APCI in a positive-ion mode, at an S/N of 5, were 44.36–153.6 fmol. The validation results showed high accuracy in the range of 93–107% and the mean interday precision for all standards was <15% at broad linear dynamic ranges (0.0244–25 nmol/mL). Good linear responses were observed with coefficients of >0.9935 in APCI/MS detection. Therefore, the facile BDEBS derivatization coupled with mass spectrometric analysis allowed the development of a highly sensitive and specific method for the quantitation of trace levels of the free and glycine-conjugated BA from human serum samples." @default.
• W2015508032 created "2016-06-24" @default.
• W2015508032 creator A5002167398 @default.
• W2015508032 creator A5003234435 @default.
• W2015508032 creator A5015718944 @default.
• W2015508032 creator A5036805518 @default.
• W2015508032 creator A5038138891 @default.
• W2015508032 creator A5049010169 @default.
• W2015508032 creator A5051219791 @default.
• W2015508032 creator A5059317683 @default.
• W2015508032 date "2006-12-01" @default.
• W2015508032 modified "2023-09-26" @default.
• W2015508032 title "Enhancement of atmospheric pressure chemical ionization for the determination of free and glycine-conjugated bile acids in human serum" @default.
• W2015508032 cites W1964119946 @default.
• W2015508032 cites W1964298112 @default.
• W2015508032 cites W1966690168 @default.
• W2015508032 cites W1971221745 @default.
• W2015508032 cites W1972153289 @default.
• W2015508032 cites W1976660814 @default.
• W2015508032 cites W1981177521 @default.
• W2015508032 cites W1989654033 @default.
• W2015508032 cites W1994758221 @default.
• W2015508032 cites W2001306715 @default.
• W2015508032 cites W2038554914 @default.
• W2015508032 cites W2041373824 @default.
• W2015508032 cites W2041670083 @default.
• W2015508032 cites W2042761114 @default.
• W2015508032 cites W2044822289 @default.
• W2015508032 cites W2049826222 @default.
• W2015508032 cites W2050115317 @default.
• W2015508032 cites W2055686596 @default.
• W2015508032 cites W2060729333 @default.
• W2015508032 cites W2069197797 @default.
• W2015508032 cites W2072511432 @default.
• W2015508032 cites W2083441243 @default.
• W2015508032 cites W2086720648 @default.
• W2015508032 cites W2096953318 @default.
• W2015508032 cites W2101494642 @default.
• W2015508032 cites W2139729706 @default.
• W2015508032 cites W2184068520 @default.
• W2015508032 cites W4300189637 @default.
• W2015508032 doi "https://doi.org/10.1002/jssc.200500463" @default.
• W2015508032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17305246" @default.
• W2015508032 hasPublicationYear "2006" @default.
• W2015508032 type Work @default.
• W2015508032 sameAs 2015508032 @default.
• W2015508032 citedByCount "18" @default.
• W2015508032 countsByYear W20155080322012 @default.
• W2015508032 countsByYear W20155080322013 @default.
• W2015508032 countsByYear W20155080322014 @default.
• W2015508032 countsByYear W20155080322015 @default.
• W2015508032 countsByYear W20155080322017 @default.
• W2015508032 countsByYear W20155080322020 @default.
• W2015508032 countsByYear W20155080322021 @default.
• W2015508032 crossrefType "journal-article" @default.
• W2015508032 hasAuthorship W2015508032A5002167398 @default.
• W2015508032 hasAuthorship W2015508032A5003234435 @default.
• W2015508032 hasAuthorship W2015508032A5015718944 @default.
• W2015508032 hasAuthorship W2015508032A5036805518 @default.
• W2015508032 hasAuthorship W2015508032A5038138891 @default.
• W2015508032 hasAuthorship W2015508032A5049010169 @default.
• W2015508032 hasAuthorship W2015508032A5051219791 @default.
• W2015508032 hasAuthorship W2015508032A5059317683 @default.
• W2015508032 hasConcept C102931765 @default.
• W2015508032 hasConcept C112613896 @default.
• W2015508032 hasConcept C113196181 @default.
• W2015508032 hasConcept C145148216 @default.
• W2015508032 hasConcept C148065180 @default.
• W2015508032 hasConcept C162356407 @default.
• W2015508032 hasConcept C178790620 @default.
• W2015508032 hasConcept C185592680 @default.
• W2015508032 hasConcept C198291218 @default.
• W2015508032 hasConcept C2776923573 @default.
• W2015508032 hasConcept C30095370 @default.
• W2015508032 hasConcept C32909587 @default.
• W2015508032 hasConcept C40875361 @default.
• W2015508032 hasConcept C43617362 @default.
• W2015508032 hasConcept C51884965 @default.
• W2015508032 hasConcept C521977710 @default.
• W2015508032 hasConceptScore W2015508032C102931765 @default.
• W2015508032 hasConceptScore W2015508032C112613896 @default.
• W2015508032 hasConceptScore W2015508032C113196181 @default.
• W2015508032 hasConceptScore W2015508032C145148216 @default.
• W2015508032 hasConceptScore W2015508032C148065180 @default.
• W2015508032 hasConceptScore W2015508032C162356407 @default.
• W2015508032 hasConceptScore W2015508032C178790620 @default.
• W2015508032 hasConceptScore W2015508032C185592680 @default.
• W2015508032 hasConceptScore W2015508032C198291218 @default.
• W2015508032 hasConceptScore W2015508032C2776923573 @default.
• W2015508032 hasConceptScore W2015508032C30095370 @default.
• W2015508032 hasConceptScore W2015508032C32909587 @default.
• W2015508032 hasConceptScore W2015508032C40875361 @default.
• W2015508032 hasConceptScore W2015508032C43617362 @default.
• W2015508032 hasConceptScore W2015508032C51884965 @default.
• W2015508032 hasConceptScore W2015508032C521977710 @default.
• W2015508032 hasIssue "18" @default.
• W2015508032 hasLocation W20155080321 @default.
• W2015508032 hasLocation W20155080322 @default.

• next