FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015518796> ?p ?o ?g. }

• W2015518796 endingPage "537" @default.
• W2015518796 startingPage "527" @default.
• W2015518796 abstract "We have analyzed a new limb mutant in the chicken that we nameoligozeugodactyly (ozd). The limbs of this mutant have a longitudinal postaxial defect, lacking the posterior element in the zeugopod(ulna/fibula) and all digits except digit 1 in the leg. Classical recombination experiments show that the limb mesoderm is the defective tissue layer in ozd limb buds. Molecular analysis revealed that theozd limbs develop in the absence of Shh expression, while all other organs express Shh and develop normally. NeitherPtc1 nor Gli1 are detectable in mutant limb buds. However,Bmp2 and dHAND are expressed in the posterior wing and leg bud mesoderm, although at lower levels than in normal embryos. Activation ofHoxd11-13 occurs normally in ozd limbs but progressively declines with time. Phase III of expression is more affected than phase II,and expression is more severely affected in the more 5′ genes. Interestingly, re-expression of Hoxd13 occurs at late stages in the distal mesoderm of ozd leg buds, correlating with formation of digit 1. Fgf8 and Fgf4 expression are initiated normally in the mutant AER but their expression is progressively downregulated in the anterior AER. Recombinant Shh protein or ZPA grafts restore normal pattern toozd limbs; however, retinoic acid fails to induce Shh in ozdlimb mesoderm. We conclude that Shh function is required for limb development distal to the elbow/knee joints, similar to the Shh-/-mouse. Accordingly we classify the limb skeletal elements as Shh dependent or independent, with the ulna/fibula and digits other than digit 1 in the leg being Shh dependent. Finally we propose that the ozd mutation is most likely a defect in a regulatory element that controls limb-specific expression of Shh." @default.
• W2015518796 created "2016-06-24" @default.
• W2015518796 creator A5018305555 @default.
• W2015518796 creator A5023356725 @default.
• W2015518796 creator A5034708451 @default.
• W2015518796 creator A5041446425 @default.
• W2015518796 creator A5055843840 @default.
• W2015518796 creator A5061139700 @default.
• W2015518796 creator A5076432454 @default.
• W2015518796 creator A5080232623 @default.
• W2015518796 creator A5089682216 @default.
• W2015518796 date "2003-02-01" @default.
• W2015518796 modified "2023-10-01" @default.
• W2015518796 title "The chick<i>oligozeugodactyly</i>(<i>ozd</i>) mutant lacks sonic hedgehog function in the limb" @default.
• W2015518796 cites W1487907335 @default.
• W2015518796 cites W1542932778 @default.
• W2015518796 cites W1565817365 @default.
• W2015518796 cites W1620398494 @default.
• W2015518796 cites W1949358569 @default.
• W2015518796 cites W1963649579 @default.
• W2015518796 cites W1966947584 @default.
• W2015518796 cites W1968416067 @default.
• W2015518796 cites W1969194487 @default.
• W2015518796 cites W1971943177 @default.
• W2015518796 cites W1973923746 @default.
• W2015518796 cites W1985109716 @default.
• W2015518796 cites W1987485173 @default.
• W2015518796 cites W1991932752 @default.
• W2015518796 cites W1993950414 @default.
• W2015518796 cites W1997580318 @default.
• W2015518796 cites W1997905438 @default.
• W2015518796 cites W2010357207 @default.
• W2015518796 cites W2022285707 @default.
• W2015518796 cites W2033702257 @default.
• W2015518796 cites W2037281919 @default.
• W2015518796 cites W2040628282 @default.
• W2015518796 cites W2055710201 @default.
• W2015518796 cites W2055792519 @default.
• W2015518796 cites W2055794792 @default.
• W2015518796 cites W2056752656 @default.
• W2015518796 cites W2056994384 @default.
• W2015518796 cites W2060505600 @default.
• W2015518796 cites W2064941027 @default.
• W2015518796 cites W2065422772 @default.
• W2015518796 cites W2065540753 @default.
• W2015518796 cites W2066479550 @default.
• W2015518796 cites W2073908723 @default.
• W2015518796 cites W2075460680 @default.
• W2015518796 cites W2075791972 @default.
• W2015518796 cites W2077802746 @default.
• W2015518796 cites W2086360430 @default.
• W2015518796 cites W2087740988 @default.
• W2015518796 cites W2089962853 @default.
• W2015518796 cites W2098159639 @default.
• W2015518796 cites W2098394909 @default.
• W2015518796 cites W2105180222 @default.
• W2015518796 cites W2105505995 @default.
• W2015518796 cites W2108707301 @default.
• W2015518796 cites W2110873651 @default.
• W2015518796 cites W2124424948 @default.
• W2015518796 cites W2140034535 @default.
• W2015518796 cites W2153145187 @default.
• W2015518796 cites W2159102936 @default.
• W2015518796 cites W2163838718 @default.
• W2015518796 cites W2345504825 @default.
• W2015518796 cites W2402629774 @default.
• W2015518796 cites W2615908011 @default.
• W2015518796 doi "https://doi.org/10.1242/dev.00245" @default.
• W2015518796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12490559" @default.
• W2015518796 hasPublicationYear "2003" @default.
• W2015518796 type Work @default.
• W2015518796 sameAs 2015518796 @default.
• W2015518796 citedByCount "121" @default.
• W2015518796 countsByYear W20155187962012 @default.
• W2015518796 countsByYear W20155187962013 @default.
• W2015518796 countsByYear W20155187962014 @default.
• W2015518796 countsByYear W20155187962015 @default.
• W2015518796 countsByYear W20155187962016 @default.
• W2015518796 countsByYear W20155187962017 @default.
• W2015518796 countsByYear W20155187962018 @default.
• W2015518796 countsByYear W20155187962019 @default.
• W2015518796 countsByYear W20155187962020 @default.
• W2015518796 countsByYear W20155187962021 @default.
• W2015518796 countsByYear W20155187962022 @default.
• W2015518796 countsByYear W20155187962023 @default.
• W2015518796 crossrefType "journal-article" @default.
• W2015518796 hasAuthorship W2015518796A5018305555 @default.
• W2015518796 hasAuthorship W2015518796A5023356725 @default.
• W2015518796 hasAuthorship W2015518796A5034708451 @default.
• W2015518796 hasAuthorship W2015518796A5041446425 @default.
• W2015518796 hasAuthorship W2015518796A5055843840 @default.
• W2015518796 hasAuthorship W2015518796A5061139700 @default.
• W2015518796 hasAuthorship W2015518796A5076432454 @default.
• W2015518796 hasAuthorship W2015518796A5080232623 @default.
• W2015518796 hasAuthorship W2015518796A5089682216 @default.
• W2015518796 hasConcept C102309675 @default.
• W2015518796 hasConcept C104317684 @default.
• W2015518796 hasConcept C105702510 @default.

• next