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- W201552169 abstract "In the rat, postoperative inhibition of gastrointestinal propulsion has been found to be accompanied by increased synthesis of norepinephrine from 14C-tyrosine. Endogenous stores of norepinephrine were not significantly modified. In this study, the peripheral sympathetic response to abdominal surgery was further examined by blocking norepinephrine synthesis with α-methyl-p-tyrosine (αMPT). The rate of decline of tissue norepinephrine stores was taken as an index of local adrenergic activity. Twelve hours after intestinal exteriorization, the αMPT-induced decrease of norepinephrine in the digestive tract was more profound than in unoperated rats. This difference was not observed in the heart. Histofluorescence studies showed that neither surgery nor αMPT treatment modified the distribution of norepinephrine in the gut wall. In operated αMPT-treated animals, there was a dramatic decrease of intensity of fluorescence in the noradrenergic nerves in the Auerbach plexus, the Meissner plexus, and in the circular muscle. The intensity of fluorescence in the perivascular adrenergic nerves was unaltered. The difference between the perivascular and the myenteric plexus in relation to depletion of norepinephrine by αMPT is probably due to a more rapid turnover of the catecholamine in the plexus. It is concluded that intestinal manipulations increase both synthesis and release of norepinephrine from noradrenergic nerves in the gut wall. This local hyperactivity of the sympathetic nerves could account for the postoperative ileus observed in man." @default.
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- W201552169 date "1974-03-01" @default.
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- W201552169 title "Chemical and Histochemical Studies of Postoperative Sympathetic Activity in the Digestive Tract in Rats" @default.
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- W201552169 doi "https://doi.org/10.1016/s0016-5085(74)80140-x" @default.
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