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- W2015523218 abstract "The mechanisms of excitability block by allethrin have been studied by means of internal electrode, internal perfusion, and sucrose-gap voltage-clamp techniques in the giant axons of the squid. Allethrin at a concentration of 10–100 μM blocked the action potential with slight depolarization either from inside or from outside the nerve membrane. The effect was partially reversible. The membrane currents associated with step depolarizations were inhibited by allethrin. With external application of allethrin, the early transient component of the membrane conductance was more strongly inhibited than the late steady-state component, whereas both components were inhibited to the same extent by internal application of allethrin. The time to peak early transient membrane current was slightly delayed either by external or by internal application of allethrin. There was an indication that with internal application of allethrin the sodium conductance increase was not as quickly inactivated as normal. The excitability block by allethrin can primarily be ascribed to the inhibition of the early transient membrane conductance. Further mechanisms of allethrin action are discussed in comparison with other blocking agents." @default.
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- W2015523218 title "Mechanism of excitation block by the insecticide allethrin applied externally and internally to squid giant axons" @default.
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- W2015523218 doi "https://doi.org/10.1016/0041-008x(67)90092-0" @default.
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