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- W2015544146 abstract "Long‐Term Mortality in Low‐Risk Adult LQTS Introduction To date, most risk stratification studies in long‐QT syndrome (LQTS) have focused on identification of high‐risk subjects. Current data on the long‐term clinical course of low‐risk adult LQTS patients are limited. Methods and Results Patients in this study were from the Rochester‐based LQTS Registry. We hypothesized that long‐term survival of LQT1‐2 patients with QTc <500 milliseconds and no cardiac symptoms before age 20 (n = 523) would be similar to that of their unaffected genotype‐negative family members (n = 1,134). Kaplan–Meier survival analysis and multivariate Cox proportional hazards regression models were used to evaluate the incidence and risk of all‐cause mortality in the study population. The low‐risk LQTS study group comprised 27% (523/1,919) of genetically confirmed LQTS Registry patients alive at age 20. The cumulative probability of all‐cause mortality between age 20 and 65 was similar in the low‐risk LQTS group and the genotype‐negative control group (4.3% and 4.4%, respectively at age 65; P = 0.49 for overall difference). Multivariate analysis showed no significant difference in the risk of all‐cause mortality between the 2 groups (HR = 0.89; 95% CI 0.33–2.43, P = 0.82). Consistent results were revealed in subgroup analyses in female and male LQTS patients and in patients with genetically identified LQT1 and LQT2 mutations. Conclusions We identified a sizeable proportion of low‐risk, adult LQTS patients with no cardiac symptoms before age 20 and QTc<500 milliseconds who had 45‐year survival similar to unaffected family members." @default.
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- W2015544146 date "2015-05-28" @default.
- W2015544146 modified "2023-09-29" @default.
- W2015544146 title "Identification of Low-Risk Adult Congenital LQTS Patients" @default.
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- W2015544146 doi "https://doi.org/10.1111/jce.12686" @default.
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