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• W2015547995 endingPage "1286" @default.
• W2015547995 startingPage "1280" @default.
• W2015547995 abstract "1 The relaxant responses of S-nitroso-l-cysteine (CysNO), S-nitroso-N-acetyl-d,l-penicillamine (SNAP), S-nitroso-N-acetyl-l-cysteine (SNAC) and S-nitrosoglutathione (GSNO) in the rat gastric fundus (forestomach) were studied and compared to the relaxant responses obtained in response to nitric oxide (NO) and electrical field stimulation (EFS, 10 s trains) of non-adrenergic non-cholinergic (NANC) nerves. 2 CysNO (10−7–3 × 10−4m) caused transient relaxation of the precontracted rat gastric fundus, comparable to the response to NO (10−4–10−4m) and EFS. SNAP, SNAC and GSNO elicited more sustained relaxations. 3 The cyclic GMP-specific phosphodiesterase inhibitor, zaprinast (3 × 10−5m), increased the relaxant effect of CysNO, SNAP and GSNO while the NO-synthase inhibitor, NG-nitro-l-arginine (l-NOARG, 3 × 10−4m) had no influence. 4 In the presence of LY 83583 (10−5m), which releases superoxide anions, the relaxant response to NO and CysNO was decreased, whereas that to all other stimuli was unaltered. The inhibitory effect of LY 83583 on CysNO-induced relaxations was prevented by superoxide dismutase (SOD, 1000 u ml−1). 5 Tissues incubated for 1 h with 5.5 × 10−4m nitroglycerin (GTN) became tolerant to GTN. In this condition, the relaxant response to 10−5m NO was maintained, while the relaxations by EFS (8 Hz) and 3 × 10−5m SNAP were significantly decreased. The reduction of the response to the other S-nitrosothiols was not significant. 6 The combination of nitrate tolerance and 10−5m LY 83583 caused a significantly larger inhibition of the relaxant response to EFS (8 Hz) than nitrate tolerance alone. The combination of LY 83583 and GTN tolerance reduced the relaxant effect of 10−5m NO to a similar extent to LY 83583 alone, while the relaxant response to 10−4m GTN was reduced to the same extent as after 1 h exposure to 5.5 × 10−4m GTN alone. 7 It is concluded that S-nitrosothiols potently relax the rat gastric fundus, possibly by a cyclic GMP-dependent mechanism and S-nitrosothiols such as SNAC and GSNO may be involved in NANC neurotransmission." @default.
• W2015547995 created "2016-06-24" @default.
• W2015547995 creator A5060029223 @default.
• W2015547995 creator A5087973639 @default.
• W2015547995 date "1994-04-01" @default.
• W2015547995 modified "2023-09-24" @default.
• W2015547995 title "Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus" @default.
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• W2015547995 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14884.x" @default.
• W2015547995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1910166" @default.
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