Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015553485> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2015553485 endingPage "219" @default.
- W2015553485 startingPage "213" @default.
- W2015553485 abstract "Although cervical cancer screening in the UK has led to reductions in the incidence of invasive disease, this programme remains flawed. We set out to examine the potential of infrared (IR) microspectroscopy to allow the profiling of cellular biochemical constituents associated with disease progression. Attenuated total reflection-Fourier Transform IR (ATR) microspectroscopy was employed to interrogate spectral differences between samples of exfoliative cervical cytology collected into liquid based cytology (LBC). These were histologically characterised as normal (n = 5), low-grade (n = 5), high-grade (n = 5) or severe dyskaryosis (? carcinoma) (n = 5). Examination of resultant spectra was coupled with principal component analysis (PCA) and subsequent linear discriminant analysis (LDA). The interrogation of LBC samples using ATR microspectroscopy with PCA–LDA facilitated the discrimination of different categories of exfoliative cytology and allowed the identification of potential biomarkers of abnormality; these occurred prominently in the IR spectral region 1200 cm−1–950 cm−1 consisting of carbohydrates, phosphate, and glycogen. Shifts in the centroids of amide I (≈1650 cm−1) and II (≈1530 cm−1) absorbance bands, indicating conformational changes to the secondary structure of intracellular proteins and associated with increasing disease progression, were also noted. This work demonstrates the potential of ATR microspectroscopy coupled with multivariate analysis to be an objective alternative to routine cytology." @default.
- W2015553485 created "2016-06-24" @default.
- W2015553485 creator A5000333809 @default.
- W2015553485 creator A5000583664 @default.
- W2015553485 creator A5006392795 @default.
- W2015553485 creator A5012629361 @default.
- W2015553485 creator A5027455752 @default.
- W2015553485 creator A5032803754 @default.
- W2015553485 creator A5045978990 @default.
- W2015553485 creator A5046887318 @default.
- W2015553485 creator A5056764919 @default.
- W2015553485 creator A5076392388 @default.
- W2015553485 date "2007-01-01" @default.
- W2015553485 modified "2023-09-25" @default.
- W2015553485 title "ATR microspectroscopy with multivariate analysis segregates grades of exfoliative cervical cytology" @default.
- W2015553485 cites W1975374743 @default.
- W2015553485 cites W1985617195 @default.
- W2015553485 cites W1990440398 @default.
- W2015553485 cites W1994721948 @default.
- W2015553485 cites W2003595062 @default.
- W2015553485 cites W2004982513 @default.
- W2015553485 cites W2007193922 @default.
- W2015553485 cites W2008976586 @default.
- W2015553485 cites W2012171819 @default.
- W2015553485 cites W2021994434 @default.
- W2015553485 cites W2022857974 @default.
- W2015553485 cites W2024971501 @default.
- W2015553485 cites W2035902235 @default.
- W2015553485 cites W2036928065 @default.
- W2015553485 cites W2060469365 @default.
- W2015553485 cites W2087983723 @default.
- W2015553485 cites W2094581205 @default.
- W2015553485 cites W2101512681 @default.
- W2015553485 cites W2117795074 @default.
- W2015553485 cites W2138556740 @default.
- W2015553485 cites W2142773345 @default.
- W2015553485 cites W2155896424 @default.
- W2015553485 cites W2165074606 @default.
- W2015553485 cites W2168252922 @default.
- W2015553485 doi "https://doi.org/10.1016/j.bbrc.2006.11.005" @default.
- W2015553485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17141660" @default.
- W2015553485 hasPublicationYear "2007" @default.
- W2015553485 type Work @default.
- W2015553485 sameAs 2015553485 @default.
- W2015553485 citedByCount "69" @default.
- W2015553485 countsByYear W20155534852012 @default.
- W2015553485 countsByYear W20155534852013 @default.
- W2015553485 countsByYear W20155534852014 @default.
- W2015553485 countsByYear W20155534852015 @default.
- W2015553485 countsByYear W20155534852016 @default.
- W2015553485 countsByYear W20155534852017 @default.
- W2015553485 countsByYear W20155534852018 @default.
- W2015553485 countsByYear W20155534852019 @default.
- W2015553485 countsByYear W20155534852020 @default.
- W2015553485 countsByYear W20155534852021 @default.
- W2015553485 countsByYear W20155534852022 @default.
- W2015553485 crossrefType "journal-article" @default.
- W2015553485 hasAuthorship W2015553485A5000333809 @default.
- W2015553485 hasAuthorship W2015553485A5000583664 @default.
- W2015553485 hasAuthorship W2015553485A5006392795 @default.
- W2015553485 hasAuthorship W2015553485A5012629361 @default.
- W2015553485 hasAuthorship W2015553485A5027455752 @default.
- W2015553485 hasAuthorship W2015553485A5032803754 @default.
- W2015553485 hasAuthorship W2015553485A5045978990 @default.
- W2015553485 hasAuthorship W2015553485A5046887318 @default.
- W2015553485 hasAuthorship W2015553485A5056764919 @default.
- W2015553485 hasAuthorship W2015553485A5076392388 @default.
- W2015553485 hasConcept C142724271 @default.
- W2015553485 hasConcept C185592680 @default.
- W2015553485 hasConcept C18823058 @default.
- W2015553485 hasConcept C71924100 @default.
- W2015553485 hasConceptScore W2015553485C142724271 @default.
- W2015553485 hasConceptScore W2015553485C185592680 @default.
- W2015553485 hasConceptScore W2015553485C18823058 @default.
- W2015553485 hasConceptScore W2015553485C71924100 @default.
- W2015553485 hasIssue "1" @default.
- W2015553485 hasLocation W20155534851 @default.
- W2015553485 hasLocation W20155534852 @default.
- W2015553485 hasOpenAccess W2015553485 @default.
- W2015553485 hasPrimaryLocation W20155534851 @default.
- W2015553485 hasRelatedWork W2007053438 @default.
- W2015553485 hasRelatedWork W2129929389 @default.
- W2015553485 hasRelatedWork W2157429957 @default.
- W2015553485 hasRelatedWork W2415006927 @default.
- W2015553485 hasRelatedWork W2424915584 @default.
- W2015553485 hasRelatedWork W2467046310 @default.
- W2015553485 hasRelatedWork W2593867956 @default.
- W2015553485 hasRelatedWork W2748952813 @default.
- W2015553485 hasRelatedWork W2899084033 @default.
- W2015553485 hasRelatedWork W3049689222 @default.
- W2015553485 hasVolume "352" @default.
- W2015553485 isParatext "false" @default.
- W2015553485 isRetracted "false" @default.
- W2015553485 magId "2015553485" @default.
- W2015553485 workType "article" @default.