Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015555488> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2015555488 endingPage "923" @default.
- W2015555488 startingPage "919" @default.
- W2015555488 abstract "Abstract The molecular mechanisms involved in barbiturate action have yet to be elucidated. Recent neurophysiological studies suggest a possible involvement of GABA synaptic events in barbiturate action. Our studies indicate that the racemic barbiturates inhibit the binding of GABA synaptic antagonist, ( 3 H) α-dihydropicrotoxinin (DHP), to rat brain membrane. Several lines of evidence suggest that DHP binding is associated with GABA receptor-ionophores, but is distinct from the GABA receptor sites. Thus, depressant barbiturates like secobarbital (IC 50 =5 μM), hexobarbital (IC 50 = 12 μM) and pentobarbital (IC 50 = 50 μM) inhibit DHP binding in the micromolar range. The interaction between pentobarbital and DHP appears to be competitive. DHP binding is also displaced by convulsant barbiturates and stereoisomers of the depressant barbiturates. The displacement curves obtained with convulsant barbiturates deviate from the Law of Mass Action, suggesting possible heterogenity of DHP binding sites. Stereoisomers of 1-methyl-5-phenyl-propylbarbituric acid (MPPB), which produce opposite pharmacological effects, inhibited DHP binding with a 10-fold difference. These findings are consistent with the neurophysiological evidence that depressant and convulsant action of barbiturates may be related to their modulation of GABA mediated inhibitory transmission. The possibility that depressant and convulsant barbiturates may modulate GABA receptor linked chloride ionophores is discussed." @default.
- W2015555488 created "2016-06-24" @default.
- W2015555488 creator A5045323788 @default.
- W2015555488 date "1980-01-01" @default.
- W2015555488 modified "2023-09-26" @default.
- W2015555488 title "Is the picrotoxinin binding site at the GABA synapse a site of action for barbiturates" @default.
- W2015555488 cites W156085772 @default.
- W2015555488 cites W1911473950 @default.
- W2015555488 cites W1969474088 @default.
- W2015555488 cites W1972402575 @default.
- W2015555488 cites W1976515336 @default.
- W2015555488 cites W1980969446 @default.
- W2015555488 cites W2011950043 @default.
- W2015555488 cites W2012970320 @default.
- W2015555488 cites W2025669874 @default.
- W2015555488 cites W2027484724 @default.
- W2015555488 cites W2030451715 @default.
- W2015555488 cites W2031577071 @default.
- W2015555488 cites W2032870022 @default.
- W2015555488 cites W2042122020 @default.
- W2015555488 cites W2042628413 @default.
- W2015555488 cites W2048972990 @default.
- W2015555488 cites W2049960383 @default.
- W2015555488 cites W2051794767 @default.
- W2015555488 cites W2067565788 @default.
- W2015555488 cites W2070889807 @default.
- W2015555488 cites W2078963381 @default.
- W2015555488 cites W2109023602 @default.
- W2015555488 cites W2120857807 @default.
- W2015555488 cites W2136768511 @default.
- W2015555488 cites W2260895936 @default.
- W2015555488 cites W2271112592 @default.
- W2015555488 cites W2334778692 @default.
- W2015555488 cites W2402867858 @default.
- W2015555488 cites W2414588402 @default.
- W2015555488 cites W2570513141 @default.
- W2015555488 doi "https://doi.org/10.1016/0361-9230(80)90155-0" @default.
- W2015555488 hasPublicationYear "1980" @default.
- W2015555488 type Work @default.
- W2015555488 sameAs 2015555488 @default.
- W2015555488 citedByCount "17" @default.
- W2015555488 crossrefType "journal-article" @default.
- W2015555488 hasAuthorship W2015555488A5045323788 @default.
- W2015555488 hasConcept C107824862 @default.
- W2015555488 hasConcept C121332964 @default.
- W2015555488 hasConcept C127445978 @default.
- W2015555488 hasConcept C134018914 @default.
- W2015555488 hasConcept C169760540 @default.
- W2015555488 hasConcept C185592680 @default.
- W2015555488 hasConcept C2780791683 @default.
- W2015555488 hasConcept C3019069312 @default.
- W2015555488 hasConcept C55493867 @default.
- W2015555488 hasConcept C62520636 @default.
- W2015555488 hasConcept C86803240 @default.
- W2015555488 hasConceptScore W2015555488C107824862 @default.
- W2015555488 hasConceptScore W2015555488C121332964 @default.
- W2015555488 hasConceptScore W2015555488C127445978 @default.
- W2015555488 hasConceptScore W2015555488C134018914 @default.
- W2015555488 hasConceptScore W2015555488C169760540 @default.
- W2015555488 hasConceptScore W2015555488C185592680 @default.
- W2015555488 hasConceptScore W2015555488C2780791683 @default.
- W2015555488 hasConceptScore W2015555488C3019069312 @default.
- W2015555488 hasConceptScore W2015555488C55493867 @default.
- W2015555488 hasConceptScore W2015555488C62520636 @default.
- W2015555488 hasConceptScore W2015555488C86803240 @default.
- W2015555488 hasLocation W20155554881 @default.
- W2015555488 hasOpenAccess W2015555488 @default.
- W2015555488 hasPrimaryLocation W20155554881 @default.
- W2015555488 hasRelatedWork W1980456323 @default.
- W2015555488 hasRelatedWork W1982959733 @default.
- W2015555488 hasRelatedWork W2087747141 @default.
- W2015555488 hasRelatedWork W2131674028 @default.
- W2015555488 hasRelatedWork W2417250347 @default.
- W2015555488 hasRelatedWork W2898063414 @default.
- W2015555488 hasRelatedWork W2911738912 @default.
- W2015555488 hasRelatedWork W3195269948 @default.
- W2015555488 hasRelatedWork W4319310789 @default.
- W2015555488 hasRelatedWork W4321178701 @default.
- W2015555488 hasVolume "5" @default.
- W2015555488 isParatext "false" @default.
- W2015555488 isRetracted "false" @default.
- W2015555488 magId "2015555488" @default.
- W2015555488 workType "article" @default.