FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015576439> ?p ?o ?g. }

• W2015576439 endingPage "56" @default.
• W2015576439 startingPage "49" @default.
• W2015576439 abstract "Recent studies have suggested roles for PCDH10 as a novel tumor suppressor gene. In our previous work, we located the core promoter of PCDH10 to a 462-bp segment of 5′-flanking region characterized by a high GC content. Here we further identified and characterized the promoter for PCDH10. Transient transfection of PC3 and LNCaP cells with a series of deleted promoter constructs indicated that the minimal promoter region was between nucleotides −144 and −99. This segment contained a CAAT box, a GT box, and a putative transcription factor binding site for AP-4. Mutational analysis identified that the CAAT box and GT box are necessary for promoter activity. Ectopic expression of NF-Ys increased reporter gene activity, whereas expression of a dominant-negative NF-YA decreased reporter gene activity. Co-transfection of Sp1/Sp3 expression plasmids enhanced reporter gene activity in a dose-dependent manner. Mithramycin A, an inhibitor of Sp–DNA interaction, reduced PCDH10 promoter activity. Electrophoretic mobility shift assays and chromatin immunoprecipitation demonstrated binding of transcription factors Sp1/Sp3 to the promoter region in vitro and in vivo. Our data show that Sp1/Sp3 and CBF/NF-Y transcription factors play a crucial role in the basal expression of the human PCDH10 gene." @default.
• W2015576439 created "2016-06-24" @default.
• W2015576439 creator A5003708516 @default.
• W2015576439 creator A5019031973 @default.
• W2015576439 creator A5022462139 @default.
• W2015576439 creator A5022518485 @default.
• W2015576439 creator A5032389020 @default.
• W2015576439 creator A5033259469 @default.
• W2015576439 creator A5053254893 @default.
• W2015576439 creator A5054971735 @default.
• W2015576439 creator A5056630426 @default.
• W2015576439 creator A5065049479 @default.
• W2015576439 creator A5083997571 @default.
• W2015576439 date "2011-04-01" @default.
• W2015576439 modified "2023-10-09" @default.
• W2015576439 title "Identification and characterization of human PCDH10 gene promoter" @default.
• W2015576439 cites W133424498 @default.
• W2015576439 cites W1501535278 @default.
• W2015576439 cites W1901437611 @default.
• W2015576439 cites W1965962153 @default.
• W2015576439 cites W1974355024 @default.
• W2015576439 cites W1990189563 @default.
• W2015576439 cites W1992742693 @default.
• W2015576439 cites W2002495914 @default.
• W2015576439 cites W2003256314 @default.
• W2015576439 cites W2009376203 @default.
• W2015576439 cites W2010736881 @default.
• W2015576439 cites W2019864695 @default.
• W2015576439 cites W2025977557 @default.
• W2015576439 cites W2026119866 @default.
• W2015576439 cites W2029967426 @default.
• W2015576439 cites W2041233862 @default.
• W2015576439 cites W2043854889 @default.
• W2015576439 cites W2044318707 @default.
• W2015576439 cites W2055026964 @default.
• W2015576439 cites W2055294254 @default.
• W2015576439 cites W2057692691 @default.
• W2015576439 cites W2061128706 @default.
• W2015576439 cites W2061710195 @default.
• W2015576439 cites W2062985556 @default.
• W2015576439 cites W2063965661 @default.
• W2015576439 cites W2085819466 @default.
• W2015576439 cites W2093640345 @default.
• W2015576439 cites W2096547907 @default.
• W2015576439 cites W2107277218 @default.
• W2015576439 cites W2109332454 @default.
• W2015576439 cites W2113197426 @default.
• W2015576439 cites W2134288198 @default.
• W2015576439 cites W2155152535 @default.
• W2015576439 cites W2155268176 @default.
• W2015576439 cites W2156525687 @default.
• W2015576439 cites W2158778721 @default.
• W2015576439 cites W2167142486 @default.
• W2015576439 cites W2169550012 @default.
• W2015576439 cites W2170138004 @default.
• W2015576439 cites W2170222791 @default.
• W2015576439 cites W2266492038 @default.
• W2015576439 cites W4230231903 @default.
• W2015576439 doi "https://doi.org/10.1016/j.gene.2011.01.001" @default.
• W2015576439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21237250" @default.
• W2015576439 hasPublicationYear "2011" @default.
• W2015576439 type Work @default.
• W2015576439 sameAs 2015576439 @default.
• W2015576439 citedByCount "12" @default.
• W2015576439 countsByYear W20155764392012 @default.
• W2015576439 countsByYear W20155764392013 @default.
• W2015576439 countsByYear W20155764392014 @default.
• W2015576439 countsByYear W20155764392017 @default.
• W2015576439 countsByYear W20155764392018 @default.
• W2015576439 crossrefType "journal-article" @default.
• W2015576439 hasAuthorship W2015576439A5003708516 @default.
• W2015576439 hasAuthorship W2015576439A5019031973 @default.
• W2015576439 hasAuthorship W2015576439A5022462139 @default.
• W2015576439 hasAuthorship W2015576439A5022518485 @default.
• W2015576439 hasAuthorship W2015576439A5032389020 @default.
• W2015576439 hasAuthorship W2015576439A5033259469 @default.
• W2015576439 hasAuthorship W2015576439A5053254893 @default.
• W2015576439 hasAuthorship W2015576439A5054971735 @default.
• W2015576439 hasAuthorship W2015576439A5056630426 @default.
• W2015576439 hasAuthorship W2015576439A5065049479 @default.
• W2015576439 hasAuthorship W2015576439A5083997571 @default.
• W2015576439 hasConcept C101762097 @default.
• W2015576439 hasConcept C104317684 @default.
• W2015576439 hasConcept C134320426 @default.
• W2015576439 hasConcept C138885662 @default.
• W2015576439 hasConcept C150194340 @default.
• W2015576439 hasConcept C153911025 @default.
• W2015576439 hasConcept C161733203 @default.
• W2015576439 hasConcept C179716448 @default.
• W2015576439 hasConcept C179926584 @default.
• W2015576439 hasConcept C3662595 @default.
• W2015576439 hasConcept C41895202 @default.
• W2015576439 hasConcept C54355233 @default.
• W2015576439 hasConcept C86339819 @default.
• W2015576439 hasConcept C86803240 @default.
• W2015576439 hasConcept C97037327 @default.
• W2015576439 hasConceptScore W2015576439C101762097 @default.
• W2015576439 hasConceptScore W2015576439C104317684 @default.

• next