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- W2015577554 abstract "In this issue of Practical Radiation Oncology, Daly and colleagues from Stanford University report on a study of cone-beam CT [computed tomography] utilization before and during neoadjuvant radiation therapy and chemotherapy for patients with rectal cancer. Their analysis included assessment of variation in rectal and bladder volumes as related to CTV [clinical target volume] design in treatment planning, with emphasis on the anterior margin at the rectal-bladder interface. They report that rectal wall location can vary significantly for patients. Overall, the rectum remained within 1.5 cm of the initial location on treatment planning CT in most patients. They concluded that an anterior margin of at least 1.5 cm beyond the posterior bladder edge provides sufficient coverage of the mesorectum in this region.1 This study is useful in that it provides recommendations for radiation treatment planning in rectal cancer patients, specifically in the definition of the anterior rectal CTV creation and anterior block edge placement. It is important to note that the CTV in the neoadjuvant treatment of rectal cancer includes not only the primary tumor itself but also the surrounding soft tissues, namely the mesorectum. This fatty “envelope” harbors potential nodal and soft tissue tumor deposits. Critically, these foci of disease may persist following resection, leading to pelvic recurrence of malignancy with its devastating morbidity and mortality. The anterior mesorectum (adjacent to the bladder) is often thin and a potentially challenging site of dissection for the surgeon. Recent patterns of failure analyses of the Dutch" @default.
- W2015577554 created "2016-06-24" @default.
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- W2015577554 date "2011-04-01" @default.
- W2015577554 modified "2023-09-30" @default.
- W2015577554 title "Rectal cancer: a moving target?" @default.
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- W2015577554 doi "https://doi.org/10.1016/j.prro.2011.02.006" @default.
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