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- W2015585219 abstract "The treatment of large, non-healing bone defects remains a clinical challenge, and has driven efforts toward the development of new approaches to engineer vascularized bone grafts. Despite great advances in bone tissue engineering over the past decade, clinical translation of stem cell-based strategies has been limited. This article discusses the hurdles blocking the effective application of stem cell-based regeneration of mature bone with perfusable vascular networks as well as avenues for potentially overcoming those hurdles. Particular focus is placed on the combination of autologous heterogeneous cell sources with key regenerative growth factors to mimic the complex cellular and biochemical environments that occur during normal bone healing. Understanding how to guide the intrinsic self-assembly mechanisms of these cells may increase their regenerative efficacy and enable in situ tissue morphogenesis. The development of more effective, safer, and simpler approaches to engineer vascularized bone grafts may bring stem cell-based approaches closer to wider clinical application." @default.
- W2015585219 created "2016-06-24" @default.
- W2015585219 creator A5075492002 @default.
- W2015585219 creator A5076017059 @default.
- W2015585219 date "2014-02-01" @default.
- W2015585219 modified "2023-10-14" @default.
- W2015585219 title "Stem cell-based approaches to engineering vascularized bone" @default.
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- W2015585219 doi "https://doi.org/10.1016/j.coche.2013.12.002" @default.
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