Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015586876> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2015586876 endingPage "281" @default.
- W2015586876 startingPage "271" @default.
- W2015586876 abstract "This study investigated the effect of experimentally-induced cholestasis in the rat on the structure and function of the zona fasciculata, the glucocorticoid secretory region of the adrenal cortex. Wistar-Furth rats (200-250g) were assigned to three groups: bile duct ligated (BDL), Sham operated (Sham) and unmodified normal control (NC). On day 14, serum bilirubin and liver histology were performed to confirm cholestasis in BDL animals together with basal 24 hour 17-hydroxycorti-costeroid excretion, adrenal histology and zona fasciculata ultrastructure in all experimental groups. Following this laparotomy, structural and functional studies were repeated on day 15 to evaluate the response of the gland to surgically induced stress. Basal 24 hr, 17-hydroxycorticoid steroid excretion was elevated in BDL animals (26.9 +/- 3.2 micrograms/24 hr) with respect to Sham (10.4 +/- 2.3) and NC groups (13.5 +/- 3.2) (p less than 0.05). Adrenal histology and ultrastructural studies demonstrated excessive accumulation of vesicles laden with glucocorticoid biogenic precursors. Following surgical stress 24 hr 17 OH corticosteroid excretion increased in all groups: BDL (31.0 +/- 3.0 micrograms/24 hr) vs Sham (15.6 +/- 1.8) and NC (14.5 +/- 2.4) Moderate alterations in zona fasciculata architecture were seen following surgery in all groups. Cholestasis induces overactivity of the zona fasciculata of the adrenal cortex, and may modify the normal metabolic responses to surgical and other stresses." @default.
- W2015586876 created "2016-06-24" @default.
- W2015586876 creator A5007245116 @default.
- W2015586876 creator A5011416300 @default.
- W2015586876 creator A5043646240 @default.
- W2015586876 creator A5047169523 @default.
- W2015586876 date "1989-01-01" @default.
- W2015586876 modified "2023-09-25" @default.
- W2015586876 title "Structural and Functional Alterations in The Zona Fasciculata of The Rat Adrenal Cortex in Obstructive Jaundice" @default.
- W2015586876 doi "https://doi.org/10.1155/1989/34079" @default.
- W2015586876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2423546" @default.
- W2015586876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2487067" @default.
- W2015586876 hasPublicationYear "1989" @default.
- W2015586876 type Work @default.
- W2015586876 sameAs 2015586876 @default.
- W2015586876 citedByCount "1" @default.
- W2015586876 crossrefType "journal-article" @default.
- W2015586876 hasAuthorship W2015586876A5007245116 @default.
- W2015586876 hasAuthorship W2015586876A5011416300 @default.
- W2015586876 hasAuthorship W2015586876A5043646240 @default.
- W2015586876 hasAuthorship W2015586876A5047169523 @default.
- W2015586876 hasBestOaLocation W20155868761 @default.
- W2015586876 hasConcept C10146269 @default.
- W2015586876 hasConcept C126322002 @default.
- W2015586876 hasConcept C134018914 @default.
- W2015586876 hasConcept C2777977426 @default.
- W2015586876 hasConcept C2778024521 @default.
- W2015586876 hasConcept C2778593092 @default.
- W2015586876 hasConcept C2778736161 @default.
- W2015586876 hasConcept C2779306644 @default.
- W2015586876 hasConcept C2780352252 @default.
- W2015586876 hasConcept C2780841215 @default.
- W2015586876 hasConcept C57742111 @default.
- W2015586876 hasConcept C71315377 @default.
- W2015586876 hasConcept C71924100 @default.
- W2015586876 hasConceptScore W2015586876C10146269 @default.
- W2015586876 hasConceptScore W2015586876C126322002 @default.
- W2015586876 hasConceptScore W2015586876C134018914 @default.
- W2015586876 hasConceptScore W2015586876C2777977426 @default.
- W2015586876 hasConceptScore W2015586876C2778024521 @default.
- W2015586876 hasConceptScore W2015586876C2778593092 @default.
- W2015586876 hasConceptScore W2015586876C2778736161 @default.
- W2015586876 hasConceptScore W2015586876C2779306644 @default.
- W2015586876 hasConceptScore W2015586876C2780352252 @default.
- W2015586876 hasConceptScore W2015586876C2780841215 @default.
- W2015586876 hasConceptScore W2015586876C57742111 @default.
- W2015586876 hasConceptScore W2015586876C71315377 @default.
- W2015586876 hasConceptScore W2015586876C71924100 @default.
- W2015586876 hasIssue "4" @default.
- W2015586876 hasLocation W20155868761 @default.
- W2015586876 hasLocation W20155868762 @default.
- W2015586876 hasLocation W20155868763 @default.
- W2015586876 hasLocation W20155868764 @default.
- W2015586876 hasOpenAccess W2015586876 @default.
- W2015586876 hasPrimaryLocation W20155868761 @default.
- W2015586876 hasRelatedWork W1966654712 @default.
- W2015586876 hasRelatedWork W1992618341 @default.
- W2015586876 hasRelatedWork W2009952201 @default.
- W2015586876 hasRelatedWork W2044827976 @default.
- W2015586876 hasRelatedWork W2065417429 @default.
- W2015586876 hasRelatedWork W2075264613 @default.
- W2015586876 hasRelatedWork W2085055194 @default.
- W2015586876 hasRelatedWork W2101834938 @default.
- W2015586876 hasRelatedWork W2125601140 @default.
- W2015586876 hasRelatedWork W2172179572 @default.
- W2015586876 hasVolume "1" @default.
- W2015586876 isParatext "false" @default.
- W2015586876 isRetracted "false" @default.
- W2015586876 magId "2015586876" @default.
- W2015586876 workType "article" @default.